Universidade de Pernambuco, Recife, Pernambuco, Brazil.
Antimicrob Agents Chemother. 2012 Apr;56(4):2205-6. doi: 10.1128/AAC.05268-11. Epub 2012 Jan 30.
This work reports the identification of the first case of a KΡC-2-producing Pseudomonas putida isolate (PP36) in Brazil. The PP36 isolate was resistant to all the antimicrobials tested except polymyxin B. In addition to the discovered bla(KPC-2) gene, genetic analysis showed the presence of a class 1 integron containing the dhfrXVb gene and the new allele arr-6, which codes for resistance to rifampin. These elements were found in an IncFI 65-kb plasmid.
本工作报道了在巴西首次发现产 KΡC-2 型金属β-内酰胺酶的铜绿假单胞菌(PP36 株)。PP36 株除对黏菌素 B 敏感外,对所有测试的抗菌药物均耐药。除发现 bla(KPC-2)基因外,遗传分析显示存在一个包含 dhfrXVb 基因和新的耐利福平等位基因 arr-6 的 1 类整合子,该整合子位于一个大小为 65kb 的 IncFI 质粒上。