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本文引用的文献

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Dissemination of blaKPC-2 by the spread of Klebsiella pneumoniae clonal complex 258 clones (ST258, ST11, ST437) and plasmids (IncFII, IncN, IncL/M) among Enterobacteriaceae species in Brazil.blaKPC-2 通过肺炎克雷伯菌克隆群 258 克隆（ST258、ST11、ST437）和质粒（IncFII、IncN、IncL/M）在巴西肠杆菌科物种中的传播。
Antimicrob Agents Chemother. 2011 Jul;55(7):3579-83. doi: 10.1128/AAC.01783-10. Epub 2011 May 16.
2
Worldwide diversity of Klebsiella pneumoniae that produce beta-lactamase blaKPC-2 gene.产生 blaKPC-2 基因的产超广谱β-内酰胺酶肺炎克雷伯菌的全球多样性。
Emerg Infect Dis. 2010 Sep;16(9):1349-56. doi: 10.3201/eid1609.091389.
3
KPC-2 producing Klebsiella pneumoniae and Escherichia coli co-infection in a catheter-related infection.产 KPC-2 肺炎克雷伯菌和大肠埃希菌合并感染导管相关感染。
Clin Microbiol Infect. 2011 Mar;17(3):380-2. doi: 10.1111/j.1469-0691.2010.03268.x.
4
Emergence of KPC-producing Pseudomonas aeruginosa in the United States.美国产KPC的铜绿假单胞菌的出现。
Antimicrob Agents Chemother. 2010 Jul;54(7):3072. doi: 10.1128/AAC.00513-10. Epub 2010 Apr 26.
5
Detection of KPC in Acinetobacter spp. in Puerto Rico.波多黎各不动杆菌属中产 KPC 的检测。
Antimicrob Agents Chemother. 2010 Mar;54(3):1354-7. doi: 10.1128/AAC.00899-09. Epub 2009 Dec 28.
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Diversity of beta-lactamases produced by ceftazidime-resistant Pseudomonas aeruginosa isolates causing bloodstream infections in Brazil.在巴西，导致血流感染的耐头孢他啶铜绿假单胞菌分离株所产生的β-内酰胺酶的多样性。
Antimicrob Agents Chemother. 2009 Sep;53(9):3908-13. doi: 10.1128/AAC.00453-09. Epub 2009 Jul 13.
7
Early dissemination of KPC-2-producing Klebsiella pneumoniae strains in Brazil.产KPC-2型肺炎克雷伯菌菌株在巴西的早期传播。
Antimicrob Agents Chemother. 2009 Jun;53(6):2702. doi: 10.1128/AAC.00089-09. Epub 2009 Mar 30.
8
Carbapenem-resistant Enterobacteriaceae: a potential threat.耐碳青霉烯类肠杆菌科细菌：一种潜在威胁。
JAMA. 2008 Dec 24;300(24):2911-3. doi: 10.1001/jama.2008.896.
9
KPC-2-producing Enterobacter cloacae and pseudomonas putida coinfection in a liver transplant recipient.一名肝移植受者发生产KPC-2的阴沟肠杆菌和恶臭假单胞菌合并感染。
Antimicrob Agents Chemother. 2009 Jan;53(1):292-4. doi: 10.1128/AAC.00931-08. Epub 2008 Oct 13.
10
First identification of Pseudomonas aeruginosa isolates producing a KPC-type carbapenem-hydrolyzing beta-lactamase.首次鉴定出产生KPC型碳青霉烯水解β-内酰胺酶的铜绿假单胞菌分离株。
Antimicrob Agents Chemother. 2007 Apr;51(4):1553-5. doi: 10.1128/AAC.01405-06. Epub 2007 Jan 29.

巴西首次描述产 KPC-2 的铜绿假单胞菌。

First description of KPC-2-producing Pseudomonas putida in Brazil.

机构信息

Universidade de Pernambuco, Recife, Pernambuco, Brazil.

出版信息

Antimicrob Agents Chemother. 2012 Apr;56(4):2205-6. doi: 10.1128/AAC.05268-11. Epub 2012 Jan 30.

DOI:10.1128/AAC.05268-11
PMID:22290946
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3318343/
Abstract

This work reports the identification of the first case of a KΡC-2-producing Pseudomonas putida isolate (PP36) in Brazil. The PP36 isolate was resistant to all the antimicrobials tested except polymyxin B. In addition to the discovered bla(KPC-2) gene, genetic analysis showed the presence of a class 1 integron containing the dhfrXVb gene and the new allele arr-6, which codes for resistance to rifampin. These elements were found in an IncFI 65-kb plasmid.

摘要

本工作报道了在巴西首次发现产 KΡC-2 型金属β-内酰胺酶的铜绿假单胞菌（PP36 株）。PP36 株除对黏菌素 B 敏感外，对所有测试的抗菌药物均耐药。除发现 bla(KPC-2)基因外，遗传分析显示存在一个包含 dhfrXVb 基因和新的耐利福平等位基因 arr-6 的 1 类整合子，该整合子位于一个大小为 65kb 的 IncFI 质粒上。