Department of Molecular, Cellular, and Developmental Biology, University of Colorado, Boulder, CO 80309, USA.
Q Rev Biophys. 2012 May;45(2):147-207. doi: 10.1017/S0033583512000017. Epub 2012 Feb 10.
Mitosis is the process by which eukaryotic cells organize and segregate their chromosomes in preparation for cell division. It is accomplished by a cellular machine composed largely of microtubules (MTs) and their associated proteins. This article reviews literature on mitosis from a biophysical point of view, drawing attention to the assembly and motility processes required to do this complex job with precision. Work from both the recent and the older literature is integrated into a description of relevant biological events and the experiments that probe their mechanisms. Theoretical work on specific subprocesses is also reviewed. Our goal is to provide a document that will expose biophysicists to the fascination of this quite amazing process and provide them with a good background from which they can pursue their own research interests in the subject.
有丝分裂是真核细胞组织和分离染色体为细胞分裂做准备的过程。这个过程由一个主要由微管（MTs）及其相关蛋白组成的细胞机器来完成。本文从生物物理的角度回顾了有丝分裂的文献，强调了完成这项复杂工作所需的组装和运动过程的精确性。将来自近期和早期文献的工作整合到对相关生物学事件及其机制探测实验的描述中。还回顾了关于特定子过程的理论工作。我们的目标是提供一份文档，让生物物理学家接触到这个非常惊人的过程的魅力，并为他们提供一个良好的背景，使他们能够在这个主题上追求自己的研究兴趣。
