Servicio de Neurología, Hospital Universitario Virgen de las Nieves, Granada, España.
Neurologia. 2013 Mar;28(2):88-94. doi: 10.1016/j.nrl.2012.03.012. Epub 2012 May 30.
The AD8 is a brief informant-based questionnaire that may also be self-administered, and which aids in identifying cognitive impairment (CI). Our goal is to assess the diagnostic accuracy (DA) of a Spanish version of that questionnaire.
Cross-sectional study of a clinical sample of patient/informant dyads including 330 subjects with suspected CI or dementia (DEM) and 71 controls. We evaluated internal consistency (Cronbach's alpha) and validity (partial correlations with GDS stage, Fototest results and functional index measure [FIM]). We assessed DA for CI vs no CI (GDS stage 3-4) using the area under the ROC curve (AUC), and the cut-off with the highest Youden index was determined to be optimal.
In the sample, 105 subjects had no CI, 99 had CI without DEM and 203 had DEM. Internal consistency was high (α 0.90, 95% confidence interval: 0.89-0.92), as were correlations with the GDS score (r=0.72, P<.001), Fototest results (r=-0.61, P<.001) and FIM (r=0.59, P<.001). The AUC for AD8 was 0.90 (95% confidence interval: 0.86-0.93), which was not significantly different from that of the Fototest (AUC 0.93, 95% confidence interval: 0.89-0.96). The optimal cut-off point was 3/4 with a sensitivity of 0.93 (95% confidence interval: 0.88-0.96) and a specificity of 0.81 (95% confidence interval: 0.72-0.88); 88.8% of the classifications were correct. Combined use of AD8 and the Fototest significantly improved the DA of both (AUC 0.96, 95% confidence interval: 0.93-0.98, P<.05).
The Spanish version of the AD8 questionnaire preserves the psychometric qualities and DA of the original. Using this test in combination with the Fototest significantly increases the DA of both tests.
AD8 是一种简短的基于信息的问卷，也可以由患者/知情者自行填写，有助于识别认知障碍（CI）。我们的目标是评估该问卷的西班牙文版本的诊断准确性（DA）。
对包括 330 例疑似 CI 或痴呆（DEM）患者/知情者和 71 例对照者在内的临床样本进行了横断面研究。我们评估了内部一致性（Cronbach's alpha）和有效性（与 GDS 分期、Fototest 结果和功能指数测量 [FIM] 的部分相关）。我们使用 ROC 曲线下面积（AUC）评估 CI 与无 CI（GDS 分期 3-4）的 DA，并确定具有最高 Youden 指数的截断值为最佳值。
在样本中，105 例无 CI，99 例有 CI 而无 DEM，203 例有 DEM。内部一致性很高（α 0.90，95%置信区间：0.89-0.92），与 GDS 评分（r=0.72，P<.001）、Fototest 结果（r=-0.61，P<.001）和 FIM（r=0.59，P<.001）呈高度相关。AD8 的 AUC 为 0.90（95%置信区间：0.86-0.93），与 Fototest（AUC 0.93，95%置信区间：0.89-0.96）无显著差异。最佳截断点为 3/4，灵敏度为 0.93（95%置信区间：0.88-0.96），特异性为 0.81（95%置信区间：0.72-0.88）；88.8%的分类正确。AD8 和 Fototest 联合使用显著提高了两者的 DA（AUC 0.96，95%置信区间：0.93-0.98，P<.05）。
AD8 问卷的西班牙文版本保留了原始问卷的心理测量质量和 DA。使用该测试与 Fototest 联合使用可显著提高两种测试的 DA。
