Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea.
J Korean Med Sci. 2012 Jun;27(6):653-60. doi: 10.3346/jkms.2012.27.6.653. Epub 2012 May 26.
The purpose of current study was to investigate associations of serum 25-hydroxyvitamin D (OHVD) levels with markers for metabolic syndrome in elderly Koreans. We conducted a panel study on 301 individuals over 60 yr old in Seoul, Korea, and repeatedly measured serum OHVD, glucose, insulin, and lipid levels. Mixed effect model and generalized estimating equations were used to investigate relationships between serum OHVD levels with marker levels for metabolic syndrome and each of its categories. Of all subjects, 76.6% were vitamin D deficient (< 50 nM) and 16.9% were insufficient (< 75 nM). Inverse association was demonstrated between serum OHVD levels and insulin (P = 0.004), triglyceride (P = 0.023) and blood pressure (systolic blood pressure: P = 0.002; diastolic blood pressure: P < 0.001). Vitamin D deficiency was found to increase risk of 'hypertriglyceridemia' category of metabolic syndrome (odds ratio: 1.73, 95% confidence interval: 1.13-2.66). In conclusion, we found from our repeated measure analysis that decreasing serum OHVD levels are associated with increasing insulin resistance, increasing serum triglyceride levels and increasing blood pressure in elderly Koreans, and confirmed on the risk of 'hypertriglyceridemia' in vitamin D deficient subjects.
本研究旨在探讨血清 25-羟维生素 D（OHVD）水平与老年韩国人代谢综合征标志物之间的关系。我们在韩国首尔对 301 名 60 岁以上的个体进行了一项面板研究，并反复测量了血清 OHVD、血糖、胰岛素和血脂水平。采用混合效应模型和广义估计方程来研究血清 OHVD 水平与代谢综合征及其各分类标志物之间的关系。在所有受试者中，76.6%的人维生素 D 缺乏（<50nm），16.9%的人不足（<75nm）。血清 OHVD 水平与胰岛素（P=0.004）、甘油三酯（P=0.023）和血压（收缩压：P=0.002；舒张压：P<0.001）呈负相关。维生素 D 缺乏会增加代谢综合征“高甘油三酯血症”类别的风险（比值比：1.73，95%置信区间：1.13-2.66）。综上所述，我们通过重复测量分析发现，血清 OHVD 水平降低与老年韩国人胰岛素抵抗增加、血清甘油三酯水平升高和血压升高有关，并证实了维生素 D 缺乏者存在“高甘油三酯血症”风险。
