Cai Weibo, Hong Hao
Departments of Radiology and Medical Physics, University of Wisconsin - Madison Madison, WI, USA ; University of Wisconsin Carbone Cancer Center Madison, WI, USA.
Am J Nucl Med Mol Imaging. 2012;2(2):136-40. Epub 2012 Mar 28.
Quantum dots (QDs) have many intriguing properties suitable for biomedical imaging applications. The poor tissue penetration of optical imaging in general, including those using QDs, has motivated the development of various QD-based dual-modality imaging agents. In this issue of AJNMMI (http://www.ajnmmi.us), Sun et al. reported the synthesis and in vitro/in vivo characterization of intrinsically radio-labeled QDs (r-QDs), where (109)Cd was incorporated into the core/shell of QDs of various compositions. These r-QDs emit in the near-infrared range, have long circulation half-life, are quite stable with low cytotoxicity, exhibit small size and low accumulation in the reticuloendothelial system, and can allow for accurate measurement of their biodistribution in mice. With these desirable features demonstrated in this study, future development and optimization will further enhance the biomedical potential of intrinsically radio-labeled QDs.
量子点（QDs）具有许多适合生物医学成像应用的有趣特性。一般来说，包括使用量子点的光学成像在内，其组织穿透性较差，这推动了各种基于量子点的双模态成像剂的开发。在本期《美国核医学与分子成像杂志》（http://www.ajnmmi.us）中，孙等人报道了本征放射性标记量子点（r-QDs）的合成及其体外/体内特性，其中（109）镉被掺入各种组成的量子点的核/壳中。这些r-QDs在近红外范围内发射，具有较长的循环半衰期，相当稳定且细胞毒性低，尺寸小且在网状内皮系统中的积累少，并且能够准确测量其在小鼠体内的生物分布。鉴于本研究中展示的这些理想特性，未来的开发和优化将进一步提升本征放射性标记量子点的生物医学潜力。
