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太空飞行中的钙:对宇航员健康、航天器操作和地球的影响。

Space flight calcium: implications for astronaut health, spacecraft operations, and Earth.

机构信息

Human Health and Performance Directorate, NASA Lyndon B. Johnson Space Center, Houston, TX 77058, USA.

出版信息

Nutrients. 2012 Dec 18;4(12):2047-68. doi: 10.3390/nu4122047.

DOI:10.3390/nu4122047
PMID:23250146
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3546622/
Abstract

The space flight environment is known to induce bone loss and, subsequently, calcium loss. The longer the mission, generally the more bone and calcium are lost. This review provides a history of bone and calcium studies related to space flight and highlights issues related to calcium excretion that the space program must consider so that urine can be recycled. It also discusses a novel technique using natural stable isotopes of calcium that will be helpful in the future to determine calcium and bone balance during space flight.

摘要

太空飞行环境已知会导致骨质流失,进而导致钙流失。任务时间越长,通常骨质和钙流失越多。本综述提供了与太空飞行相关的骨和钙研究的历史,并强调了太空计划必须考虑的与钙排泄相关的问题,以便可以回收尿液。它还讨论了一种使用钙的天然稳定同位素的新技术,该技术将有助于未来确定太空飞行期间的钙和骨平衡。

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Osteoporos Int. 2013 Jul;24(7):2105-14. doi: 10.1007/s00198-012-2243-z. Epub 2013 Jan 19.
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Bone metabolism and nutritional status during 30-day head-down-tilt bed rest.卧床 30 天期间的骨代谢和营养状况。
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Rapidly assessing changes in bone mineral balance using natural stable calcium isotopes.
对16周龄雌性C57BL/6J小鼠进行37天的微重力暴露,与负重骨骼部位特有的骨质流失有关。
PLoS One. 2025 Mar 26;20(3):e0317307. doi: 10.1371/journal.pone.0317307. eCollection 2025.
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Effects of Space Flight on Inflammasome Activation in the Brain of Mice.太空飞行对小鼠大脑中炎性小体激活的影响。
Cells. 2025 Mar 12;14(6):417. doi: 10.3390/cells14060417.
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To boldly go where no microRNAs have gone before: spaceflight impact on risk for small-for-gestational-age infants.勇敢地走向微 RNA 未曾涉足的领域:太空飞行对小于胎龄儿风险的影响。
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