莱姆病：综述。
Lyme disease: review.
机构信息
Chair of Gastroenterology, Hepatology and Infectious Diseases, Jagiellonian University Medical College, Krakow, Poland.
出版信息
Arch Med Sci. 2012 Dec 20;8(6):978-82. doi: 10.5114/aoms.2012.30948. Epub 2012 Oct 8.
Abstract
Lyme disease is a multi-organ animal-borne disease, caused by spirochetes of Borrelia burgdorferi (Bb), which typically affect the skin, nervous system, musculoskeletal system and heart. A history of confirmed exposure to tick bites, typical signs and symptoms of Lyme borreliosis and positive tests for anti-Bb antibodies, are the basis of a diagnosis. A two-step diagnosis is necessary: the first step is based on a high sensitivity ELISA test with positive results confirmed by a more specific Western blot assay. Antibiotic therapy is curative in most cases, but some patients develop chronic symptoms, which do not respond to antibiotics. The aim of this review is to summarize our current knowledge of the symptoms, clinical diagnosis and treatment of Lyme borreliosis.
摘要
莱姆病是一种多器官动物传播疾病，由伯氏疏螺旋体（Bb）螺旋体引起，通常影响皮肤、神经系统、肌肉骨骼系统和心脏。确诊的蜱虫叮咬史、莱姆病的典型体征和症状以及抗-Bb 抗体检测阳性是诊断的基础。两步诊断是必要的：第一步基于高灵敏度 ELISA 检测，阳性结果通过更特异的 Western blot 检测确认。抗生素治疗在大多数情况下是有效的，但有些患者出现慢性症状，对抗生素无反应。本综述旨在总结我们目前对莱姆病的症状、临床诊断和治疗的认识。
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