Wallace H Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA 30332, USA.
Nanomedicine (Lond). 2013 Aug;8(8):1323-33. doi: 10.2217/nnm.13.117.
Nanoparticle-mediated hyperthermia for cancer therapy is a growing area of cancer nanomedicine because of the potential for localized and targeted destruction of cancer cells. Localized hyperthermal effects are dependent on many factors, including nanoparticle size and shape, excitation wavelength and power, and tissue properties. Computational modeling is an important tool for investigating and optimizing these parameters. In this review, we focus on computational modeling of magnetic and gold nanoparticle-mediated hyperthermia, followed by a discussion of new opportunities and challenges.
纳米颗粒介导的热疗在癌症治疗中是癌症纳米医学的一个新兴领域，因为它有可能实现对癌细胞的局部和靶向破坏。局部热效应取决于许多因素，包括纳米颗粒的大小和形状、激发波长和功率以及组织特性。计算建模是研究和优化这些参数的重要工具。在本综述中，我们重点介绍了磁性和金纳米颗粒介导的热疗的计算建模，随后讨论了新的机会和挑战。
