用于活性氧和氮物种活体成像的半导体聚合物纳米探针。
Semiconducting polymer nanoprobe for in vivo imaging of reactive oxygen and nitrogen species.
机构信息
Molecular Imaging Program at Stanford, Departments of Radiology and Chemistry, Stanford University, 1201 Welch Road, Stanford, CA 94305-5484 (USA).
出版信息
Angew Chem Int Ed Engl. 2013 Sep 23;52(39):10325-9. doi: 10.1002/anie.201303420. Epub 2013 Aug 13.
Abstract
Semiconducting polymer nanoparticles are utilized as a free-radical inert and light-harvesting nanoplatform for molecular imaging of reactive oxygen and nitrogen species (RONS). With its RONS-sensitive fluorescence, good biodistribution and passive targeting ability to leaky inflammatory vasculature, this nanoprobe permits detection of RONS in the microenvironment of spontaneous bacterial infection following systemic administration.
摘要
半导体聚合物纳米粒子可用作自由基惰性和光捕获纳米平台，用于活性氧和氮物种（RONS）的分子成像。该纳米探针具有 RONS 敏感荧光、良好的生物分布和对渗漏性炎症血管的被动靶向能力，允许在全身性给药后自发细菌感染的微环境中检测 RONS。
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