Mohammadi Mehrnoosh, Riyahi Bakhtiari Alireza, Khodabandeh Saber
Environmental Forensic Laboratory, Department of Environmental Sciences, Faculty of Natural Resource and Marine Science, Tarbiat Modares University, P.O. Box 64414-356, Noor, Mazandaran, Iran.
Faculty of Marine Science, Tarbiat Modares University, Tehran, Iran.
J Toxicol. 2014;2014:413870. doi: 10.1155/2014/413870. Epub 2014 Feb 11.
Breast cancer is the major cause of cancer morbidity and mortality between women in the world. Metals involved in environmental toxicology are closely related to tumor growth and cancer. On the other hand, some metals such as selenium have anticarcinogenic properties. The aim of this study is to determine the concentration of cadmium, lead, mercury, and selenium in separated parts of tegmen, tumor, tumor adiposity, and tegmen adiposity of 14 breast cancer tissues which have been analyzed by graphite furnace atomic absorption (AA-670) and ICP-OES (ULTIMA 2CE). Our results show that Se and Hg have maximum and minimum concentration, respectively. Statistical analysis reveals no significant differences between metal accumulations in different parts of cancer tissues (P > 0.05) and this observation might be due to the close relation of separated parts of fatty breast organ. Thus, we could conclude that a high level of these heavy metals is accumulated in Iranian cancerous breasts and their presence can be one of the reasons of cancer appearance.
乳腺癌是全球女性癌症发病和死亡的主要原因。环境毒理学中涉及的金属与肿瘤生长和癌症密切相关。另一方面，一些金属如硒具有抗癌特性。本研究的目的是测定14例乳腺癌组织的被膜、肿瘤、肿瘤脂肪组织和被膜脂肪组织各分离部分中镉、铅、汞和硒的浓度，这些组织已通过石墨炉原子吸收法（AA - 670）和电感耦合等离子体发射光谱法（ULTIMA 2CE）进行分析。我们的结果表明，硒和汞的浓度分别最高和最低。统计分析显示癌组织不同部分的金属积累之间无显著差异（P > 0.05），这一观察结果可能是由于乳腺脂肪器官各分离部分关系密切所致。因此，我们可以得出结论，伊朗患癌乳房中积累了高水平的这些重金属，它们的存在可能是癌症发生的原因之一。
