Koneru Suneetha, Tanikonda Rambabu
Department of Periodontics, Vishnu Dental College, Bhimavaram, Andhra Pradesh, India.
Department of Conservative Dentistry and Endodontics, Vishnu Dental College, Bhimavaram, Andhra Pradesh, India.
Dent Res J (Isfahan). 2014 Jan;11(1):11-5.
Human saliva plays an important role in the health of the oral cavity and of the body as a whole. Salivary diagnostics is a dynamic and emerging field in the diagnosis of oral and systemic diseases. Saliva reflects the physiologic state of the body, including emotional, endocrinal, nutritional, and metabolic variations. The collection of saliva samples is noninvasive, safe, and inexpensive. Traditional clinical criteria are insufficient for determining sites of active disease, for monitoring the response to therapy, or for measuring the degree of susceptibility to future disease progression. Salivaomics includes five diagnostic alphabets proteins, mRNAs, miRNAs, metabolic compounds, and microbes offering substantial advantages because disease states may be accompanied by detectable changes. Salivaomics, the future of saliva-based techniques for early diagnosis of dental diseases, is promising and may offer a robust alternative for clinicians to use in the near future to make clinical decisions.
人类唾液在口腔健康乃至整个身体的健康中都起着重要作用。唾液诊断是口腔疾病和全身性疾病诊断领域中一个充满活力且不断发展的领域。唾液反映了身体的生理状态，包括情绪、内分泌、营养和代谢变化。唾液样本的采集是非侵入性的、安全且廉价的。传统临床标准在确定活动性疾病部位、监测治疗反应或衡量对未来疾病进展的易感性程度方面并不充分。唾液组学包括蛋白质、信使核糖核酸（mRNA）、微小核糖核酸（miRNA）、代谢化合物和微生物这五个诊断要素，具有显著优势，因为疾病状态可能伴随着可检测到的变化。唾液组学作为基于唾液的牙科疾病早期诊断技术的未来发展方向，前景广阔，可能在不久的将来为临床医生提供一种可靠的替代方法，用于做出临床决策。
