Orisakwe Orish Ebere
Department of Experimental Pharmacology and Clinical Pharmacy, Toxicology Unit, Clinical Pharmacy, Faculty of Pharmacy, University of Port-Hacourt, Rivers State, Nigeria.
N Am J Med Sci. 2014 Aug;6(8):370-6. doi: 10.4103/1947-2714.139283.
Psychiatric disorders are associated with long-term disability and huge social and economic costs. The possible influence of heavy metals exposure on public health remains a matter of concern. A recurring research question that persisted among researchers in neuropsychiatry has been "are psychiatric patients more likely to have a high body burden of lead or other heavy metals?" This is an update account on the role of lead and cadmium in psychiatry. This review, which has employed search words like "lead and cadmium in psychiatry", "lead and cadmium in schizophrenia", "lead and cadmium in psychosis" in citation indices such as PubMed, Google Scholar, Scirus, and Scopus. A total of 415 articles were found; 60 fulfiled the inclusion criteria. Evidence-based information suggests that lead and cadmium may be involved in psychiatry. Should environmental lead and cadmium be implicated in the etiogenesis of psychiatry given the characteristic high environmental pollution in Sub Sahara Africa, it is worthwhile for toxicologists and scientists in Sub-Sahara Africa to investigate if lead and cadmium can become additional biomarkers in the diagnosis of psychiatric disorders.
精神疾病与长期残疾以及巨大的社会和经济成本相关。重金属暴露对公众健康的潜在影响仍是一个令人担忧的问题。神经精神病学研究人员一直反复探讨的一个问题是“精神科患者是否更有可能体内铅或其他重金属含量过高？” 这是一篇关于铅和镉在精神病学中作用的最新报道。本综述在诸如PubMed、谷歌学术、Scirus和Scopus等文献索引中使用了 “精神病学中的铅和镉”、“精神分裂症中的铅和镉”、“精神病中的铅和镉” 等检索词。共找到415篇文章；60篇符合纳入标准。循证信息表明铅和镉可能与精神病学有关。鉴于撒哈拉以南非洲地区环境污染严重的特点，环境中的铅和镉是否与精神病的病因有关，撒哈拉以南非洲的毒理学家和科学家研究铅和镉是否能成为精神疾病诊断中的额外生物标志物是值得的。
