Leung Cindy W, Laraia Barbara A, Needham Belinda L, Rehkopf David H, Adler Nancy E, Lin Jue, Blackburn Elizabeth H, Epel Elissa S
Cindy W. Leung is with the Center for Health and Community, School of Medicine, University of California, San Francisco. Barbara A. Laraia is with the School of Public Health, University of California, Berkeley. Belinda Needham is with the Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor. David H. Rehkopf is with the Department of Medicine, Stanford University, Palo Alto, CA. Nancy E. Adler and Elissa S. Epel are with the Center for Health and Community and the Department of Psychiatry, School of Medicine, University of California, San Francisco. Jue Lin and Elizabeth H. Blackburn are with the Department of Biochemistry and Biophysics, University of California, San Francisco.
Am J Public Health. 2014 Dec;104(12):2425-31. doi: 10.2105/AJPH.2014.302151. Epub 2014 Oct 16.
We tested whether leukocyte telomere length maintenance, which underlies healthy cellular aging, provides a link between sugar-sweetened beverage (SSB) consumption and the risk of cardiometabolic disease.
We examined cross-sectional associations between the consumption of SSBs, diet soda, and fruit juice and telomere length in a nationally representative sample of healthy adults. The study population included 5309 US adults, aged 20 to 65 years, with no history of diabetes or cardiovascular disease, from the 1999 to 2002 National Health and Nutrition Examination Surveys. Leukocyte telomere length was assayed from DNA specimens. Diet was assessed using 24-hour dietary recalls. Associations were examined using multivariate linear regression for the outcome of log-transformed telomere length.
After adjustment for sociodemographic and health-related characteristics, sugar-sweetened soda consumption was associated with shorter telomeres (b = -0.010; 95% confidence interval [CI] = -0.020, -0.001; P = .04). Consumption of 100% fruit juice was marginally associated with longer telomeres (b = 0.016; 95% CI = -0.000, 0.033; P = .05). No significant associations were observed between consumption of diet sodas or noncarbonated SSBs and telomere length.
Regular consumption of sugar-sweetened sodas might influence metabolic disease development through accelerated cell aging.
我们测试了白细胞端粒长度维持（健康细胞衰老的基础）是否能在含糖饮料（SSB）消费与心脏代谢疾病风险之间建立联系。
我们在一个具有全国代表性的健康成年人样本中，研究了SSB、无糖汽水和果汁的消费与端粒长度之间的横断面关联。研究人群包括来自1999年至2002年国家健康和营养检查调查的5309名20至65岁、无糖尿病或心血管疾病史的美国成年人。从DNA样本中检测白细胞端粒长度。使用24小时饮食回忆法评估饮食情况。使用多变量线性回归分析对数转换后的端粒长度结果的关联。
在调整社会人口统计学和健康相关特征后，含糖汽水的消费与较短的端粒相关（b = -0.010；95%置信区间[CI] = -0.020，-0.001；P = 0.04）。100%果汁的消费与较长的端粒有微弱关联（b = 0.016；95% CI = -0.000，0.033；P = 0.05）。未观察到无糖汽水或非碳酸SSB的消费与端粒长度之间有显著关联。
经常饮用含糖汽水可能通过加速细胞衰老影响代谢疾病的发展。
