Santolaria Sanz Elena, Cerviño Alejandro, Queiros Antonio, Villa-Collar Cesar, Lopes-Ferreira Daniela, González-Méijome Jose Manuel
Private Practice, Onda, 12200 Castellon, Spain ; Optometry Research Group, Department of Optics, Universidad de Valencia, 46100 Valencia, Spain.
Optometry Research Group, Department of Optics, Universidad de Valencia, 46100 Valencia, Spain.
Biomed Res Int. 2015;2015:278425. doi: 10.1155/2015/278425. Epub 2015 Jan 28.
Quantifying adaptation to light distortion of subjects undergoing orthokeratology (OK) for myopia during the first month of treatment.
Twenty-nine healthy volunteers (age: 22.34 ± 8.08 years) with mean spherical equivalent refractive error -2.10 ± 0.93D were evaluated at baseline and days 1, 7, 15, and 30 of OK treatment. Light distortion was determined using an experimental prototype. Corneal aberrations were derived from corneal topography for different pupil sizes. Contrast sensitivity function (CSF) was analyzed for frequencies of 1.50, 2.12, 3.00, 4.24, 6.00, 8.49, 12.00, 16.97, and 24.00 cpd under photopic conditions.
Average monocular values of all light distortion parameters measured increased significantly on day 1, returning to baseline after 1 week (P < 0.05 in all cases). Spherical-like aberration stabilized on day 7 for all pupil diameters, while coma-like for smaller pupils only. CSF was significantly reduced on day 1 for all spatial frequencies except for 1.5 cpd, returning to baseline afterwards. Significant correlation was found between light distortion and contrast sensitivity for middle and high frequencies (P < 0.05) after 15 days.
Despite consistently increased levels of corneal aberrations, light distortion tends to return to baseline after one week of treatment, suggesting that neural adaptation is capable of overcoming optical quality degradation.
量化近视患者在角膜塑形术（OK）治疗的第一个月中对光畸变的适应性。
对29名健康志愿者（年龄：22.34±8.08岁）进行评估，这些志愿者的平均球镜等效屈光不正为-2.10±0.93D，在基线以及OK治疗的第1、7、15和30天进行检查。使用实验原型确定光畸变。从不同瞳孔大小的角膜地形图得出角膜像差。在明视条件下，分析1.50、2.12、3.00、4.24、6.00、8.49、12.00、16.97和24.00 cpd频率下的对比敏感度函数（CSF）。
所有测量的光畸变参数的平均单眼值在第1天显著增加，1周后恢复到基线水平（所有情况P<0.05）。所有瞳孔直径的类球差在第7天稳定，而类彗差仅在较小瞳孔时稳定。除1.5 cpd外，所有空间频率的CSF在第1天均显著降低，之后恢复到基线水平。15天后，中高频的光畸变与对比敏感度之间存在显著相关性（P<0.05）。
尽管角膜像差水平持续增加，但光畸变在治疗1周后往往会恢复到基线水平，这表明神经适应性能够克服光学质量下降的问题。
