Kyriakopoulos Anthony M, Dinda Biswanath
Nasco AD Biotechnology Laboratory, 11 Sachtouri Street, 18536 Pireus, Greece.
Department of Chemistry, Tripura University, Suryamaninagar 799 022 Tripura, India.
Molecules. 2015 Jun 17;20(6):11202-18. doi: 10.3390/molecules200611202.
The medicinal properties of Cornus mas L. (=Cornus mascula L.), Cornaceae, are well described in Hippocratian documents, and recent research provides experimental evidence for some of these properties. However, the chemical components of Cornus mas L. that may be of pharmaceutical importance are relatively unstable. In this respect a novel methodology for plant nutrient element extraction that provides favorable conditions for simultaneous stabilization of such fragile and unstable structures has been devised. Using this methodology, medicinal preparations derived from Cornus mas L. fresh fruits, proved to possess significant antimicrobial activity selective against S. aureus and P. aeruginosa. This effect became apparent with the addition of sodium bromide in the extraction procedure and varied with the ion availability during extraction. The identification of novel agents with potent antimicrobial activity against these species is of medical importance to overcome the problem of universal antibiotic resistance.
山茱萸（Cornus mas L. = Cornus mascula L.），山茱萸科，其药用特性在希波克拉底文献中有详细记载，近期研究为其中一些特性提供了实验证据。然而，山茱萸中可能具有药物重要性的化学成分相对不稳定。在这方面，已经设计出一种新型植物营养元素提取方法，该方法为同时稳定此类脆弱和不稳定结构提供了有利条件。使用这种方法，从山茱萸新鲜果实中提取的药用制剂被证明对金黄色葡萄球菌和铜绿假单胞菌具有显著的选择性抗菌活性。在提取过程中加入溴化钠后，这种效果变得明显，并且随提取过程中离子的可用性而变化。鉴定对这些物种具有强效抗菌活性的新型药物对于克服普遍的抗生素耐药性问题具有医学重要性。
