van der Wurff Inge S M, von Schacky Clemens, Berge Kjetil, Zeegers Maurice P, Kirschner Paul A, de Groot Renate H M
Welten Institute, Research Centre for Learning, Teaching, and Technology, Open University of the Netherlands, Heerlen 6419 AT, The Netherlands.
Omegametrix, Martinsried 82 152, Germany.
Nutrients. 2016 Jan 2;8(1):13. doi: 10.3390/nu8010013.
The impact of omega-3 long-chain polyunsaturated fatty acids (LCPUFAs) on cognition is heavily debated. In the current study, the possible association between omega-3 LCPUFAs in blood and cognitive performance of 266 typically developing adolescents aged 13-15 years is investigated. Baseline data from Food2Learn, a double-blind and randomized placebo controlled krill oil supplementation trial in typically developing adolescents, were used for the current study. The Omega-3 Index was determined with blood from a finger prick. At baseline, participants finished a neuropsychological test battery consisting of the Letter Digit Substitution Test (LDST), D2 test of attention, Digit Span Forward and Backward, Concept Shifting Test and Stroop test. Data were analyzed with multiple regression analyses with correction for covariates. The average Omega-3 Index was 3.83% (SD 0.60). Regression analyses between the Omega-3 Index and the outcome parameters revealed significant associations with scores on two of the nine parameters. The association between the Omega-3 Index and both scores on the LDST (β = 0.136 and p = 0.039), and the number of errors of omission on the D2 (β = -0.053 and p = 0.007). This is a possible indication for a higher information processing speed and less impulsivity in those with a higher Omega-3 Index.
ω-3长链多不饱和脂肪酸（LCPUFAs）对认知的影响存在激烈争论。在本研究中，调查了266名13至15岁发育正常的青少年血液中ω-3 LCPUFAs与认知表现之间的可能关联。本研究使用了Food2Learn的基线数据，这是一项针对发育正常青少年的双盲随机安慰剂对照磷虾油补充试验。通过手指采血测定ω-3指数。在基线时，参与者完成了一套神经心理测试，包括字母数字替换测试（LDST）、注意力D2测试、数字广度顺背和倒背、概念转换测试和斯特鲁普测试。采用多元回归分析并对协变量进行校正来分析数据。ω-3指数的平均值为3.83%（标准差0.60）。ω-3指数与结果参数之间的回归分析显示，与九个参数中的两个参数的得分存在显著关联。ω-3指数与LDST的得分（β = 0.136，p = 0.039）以及D2测试中的遗漏错误数量（β = -0.053，p = 0.007）均有关联。这可能表明ω-3指数较高的人信息处理速度更快且冲动性更低。
