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埃塞俄比亚南部阿尔巴明奇医院接受常规产前检查的孕妇中乙型肝炎病毒感染的血清流行率及预测因素

Seroprevalence and Predictors of Hepatitis B Virus Infection among Pregnant Women Attending Routine Antenatal Care in Arba Minch Hospital, South Ethiopia.

作者信息

Yohanes Tsegaye, Zerdo Zerihun, Chufamo Nega

机构信息

Department of Medical Laboratory Science, Arba Minch University, P.O. Box 21, Arba Minch, Ethiopia.

School of Medicine, Department of Obstetrics and Gynecology, Arba Minch University, P.O. Box 21, Arba Minch, Ethiopia.

出版信息

Hepat Res Treat. 2016;2016:9290163. doi: 10.1155/2016/9290163. Epub 2016 Jan 24.

Abstract

Hepatitis B virus (HBV) is a serious cause of liver disease affecting millions of people throughout the world. When HBV is acquired during pregnancy, prenatal transmission can occur to the fetus. Therefore, this study is aimed at estimating seroprevalence and associated factors of HBV infection among pregnant women attending Antenatal Clinic (ANC) of Arba Minch Hospital, Southern Ethiopia. A facility based cross-sectional study was conducted on 232 pregnant women visiting ANC from February to April, 2015. Data regarding sociodemographic and associated factors were gathered using questionnaire. Serum samples were tested for hepatitis B surface antigen (HBsAg) by Enzyme Linked Immunosorbent Assay. Data was analyzed using SPSS version 20. The overall seroprevalence of HBV infection was 4.3% (95% CI: 2.2-6.9%). Multivariate analysis showed that history of abortion (AOR = 7.775; 95% CI: 1.538-39.301) and having multiple sexual partners (AOR = 7.189; 95% CI: 1.039-49.755) were independent predictors of HBsAg seropositivity. In conclusion, the prevalence of HBV infection is intermediate. Therefore, screening HBV infection should be routine part of ANC; health information on having single sexual partner for women of childbearing age and on following aseptic techniques during abortion should be provided to health facilities working on abortion.

摘要

乙型肝炎病毒(HBV)是导致肝病的一个重要原因,影响着全球数百万人。如果在孕期感染HBV,可能会发生母婴传播。因此,本研究旨在评估埃塞俄比亚南部阿尔巴明奇医院产前检查门诊(ANC)孕妇中HBV感染的血清流行率及其相关因素。2015年2月至4月,对232名前来ANC就诊的孕妇开展了一项基于机构的横断面研究。通过问卷调查收集社会人口学及相关因素的数据。采用酶联免疫吸附测定法检测血清样本中的乙型肝炎表面抗原(HBsAg)。使用SPSS 20版软件进行数据分析。HBV感染的总体血清流行率为4.3%(95%CI:2.2 - 6.9%)。多因素分析显示,流产史(调整后比值比[AOR]=7.775;95%CI:1.538 - 39.301)和有多个性伴侣(AOR = 7.189;95%CI:1.039 - 49.755)是HBsAg血清阳性的独立预测因素。总之,HBV感染率处于中等水平。因此,HBV感染筛查应成为产前检查门诊的常规项目;应向从事流产手术的医疗机构提供关于育龄妇女保持单一性伴侣以及流产时遵循无菌技术的健康信息。

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