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[痴呆症的预防策略]

[Preventive strategies for dementia].

作者信息

Müller Patrick, Schmicker Marlen, Müller Notger G

机构信息

AG Neuroprotektion, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Leipziger Str. 44/Haus 64, 39120, Magdeburg, Deutschland.

Universitätsklinik für Neurologie, Otto-von-Guericke-Universität, Magdeburg, Deutschland.

出版信息

Z Gerontol Geriatr. 2017 May;50(Suppl 2):89-95. doi: 10.1007/s00391-017-1202-x. Epub 2017 Feb 27.

Abstract

In the context of the demographically induced increase in the prevalence of dementia and the simultaneous lack of causal pharmacological therapies, preventive approaches are gaining in importance. By reducing risk factors and with measures which induce neuroplasticity successful aging can be supported. This article summarizes the current developments in preventing dementia by modification of life style factors. The main focus lies on the impact of cognitive and physical activity on neuroprotection. A promising approach combines both activities within a dance training program. Further studies that meet the demanding criteria of a randomized clinical trial are urgently needed.

摘要

在人口结构变化导致痴呆症患病率上升且同时缺乏因果性药物治疗的背景下,预防方法正变得越来越重要。通过降低风险因素以及采取诱导神经可塑性的措施,可以支持成功老龄化。本文总结了通过改变生活方式因素预防痴呆症的当前进展。主要重点在于认知和身体活动对神经保护的影响。一种有前景的方法是在舞蹈训练项目中将这两种活动结合起来。迫切需要开展符合随机临床试验严格标准的进一步研究。

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