Akhavan Ali, Arbabzadeh Farahnaz, Bouzari Majid, Razavi Sayed Mohammad, Davoudi Amin
Dental Materials Research Center, Department of Endodontics, Dental School, Isfahan University of Medical Sciences, Isfahan, Iran.
Dental Research Center, Department of Operative Dentistry, Dental School, Isfahan University of Medical Sciences, Isfahan, Iran.
Iran Endod J. 2017 Spring;12(2):226-230. doi: 10.22037/iej.2017.44.
Pulp vitality and its continuous dentin prodution are essential for long-term success of direct pulp capping (DPC). The aim of present study was to evaluate the histopathological response of the canine pulp following DPC using either different dentin adhesive resins (DAR), calcium hydroxide (CH) or mineral trioxide aggregate (MTA).
DPC was done on 72 dog's teeth using 6 types of dental materials (=12) (4 types of DAR, white MTA and CH). Therefore, six healthy dogs were anesthetized and 2 teeth from each dog were allocated to either type of mentioned DPC agents. The dental pulps were exposed mechanically by drilling in the center of class V cavities. The different types of capping materials included DARS (Clearfil S3 Bond, Optibond FL, Single Bond and Clearfil SE Bond), white MTA and CH. After 7, 21 and 63 days, two dogs were euthanized in each interval. Microscopic evaluations were done according to following criteria: intensity of inflammation, presence of necrosis and formation of hard tissue. The recorded data were analyzed by the Kruskal-Wallis, Friedman, Cochran's and Fisher's exact tests using SPSS software version 12 at significant level of 0.05.
No significant differences were found regarding necrosis among DPC materials (>0.05). However, MTA caused higher amount of hard tissue formation after 63 days in comparison with 21 days.
MTA provided the highest degree of hard tissue formation after 63 days. However, further studies should be performed for administering a definitive material.
牙髓活力及其持续的牙本质生成对于直接盖髓术（DPC）的长期成功至关重要。本研究的目的是评估使用不同的牙本质粘结树脂（DAR）、氢氧化钙（CH）或三氧化矿物凝聚体（MTA）进行DPC后犬牙髓的组织病理学反应。
使用6种牙科材料（=12）（4种DAR、白色MTA和CH）对72颗犬牙进行DPC。因此，对6只健康犬进行麻醉，每只犬的2颗牙齿被分配到上述每种DPC剂类型中。通过在V类洞中心钻孔机械暴露牙髓。不同类型的盖髓材料包括DARS（Clearfil S3 Bond、Optibond FL、Single Bond和Clearfil SE Bond）、白色MTA和CH。在7天、21天和63天后，每个时间段安乐死2只犬。根据以下标准进行显微镜评估：炎症强度、坏死情况和硬组织形成情况。使用SPSS软件版本12，通过Kruskal-Wallis、Friedman、Cochran和Fisher精确检验对记录的数据进行分析，显著性水平为0.05。
DPC材料之间在坏死方面未发现显著差异（>0.05）。然而，与21天时相比，MTA在63天后导致更多的硬组织形成。
MTA在63天后提供了最高程度的硬组织形成。然而，应进行进一步研究以确定一种确定性材料。
