草本挥发油提取物对多重耐药菌的杀菌活性
Bactericidal activity of herbal volatile oil extracts against multidrug-resistant .
作者信息
Intorasoot Amornrat, Chornchoem Piyaorn, Sookkhee Siriwoot, Intorasoot Sorasak
机构信息
Department of Microbiology, Faculty of Medicine, Chiang Mai University, Chiang Mai 50200, Thailand.
Department of Medical Technology, Division of Clinical Microbiology, Faculty of Associated Medical Sciences, Chiang Mai University, Chiang Mai 50200, Thailand.
出版信息
J Intercult Ethnopharmacol. 2017 Apr 21;6(2):218-222. doi: 10.5455/jice.20170411091159. eCollection 2017 Apr-Jun.
AIM
The aim of the study is to investigate the antibacterial activity of 10 volatile oils extracted from medicinal plants, including galangal ( Linn.), ginger (), plai ( Roxb.), lime (), kaffir lime ( DC.), sweet basil ( Linn.), tree basil (), lemongrass ( DC.), clove (), and cinnamon () against four standard strains of , , , , and 30 clinical isolates of multidrug-resistant (MDR-).
MATERIALS AND METHODS
Agar diffusion, minimum inhibitory concentration, and minimum bactericidal concentration (MBC) were employed for the determination of bactericidal activity of water distilled medicinal plants. Tea tree oil () was used as positive control in this study.
RESULTS
The results indicated the volatile oil extracted from cinnamon exhibited potent antibacterial activity against the most common human pathogens, , , , and . Most of volatile oil extracts were less effective against non-fermentative bacteria, . In addition, volatile oil extracted from cinnamon, clove, and tree basil possessed potent bactericidal activity against MDR- with MBC of 0.5, 1, and 2 mg/mL, respectively.
CONCLUSIONS
The volatile oil extracts would be useful as alternative natural product for the treatment of the most common human pathogens and MDR- infections.
目的
本研究旨在调查从药用植物中提取的10种挥发油的抗菌活性，这些植物包括高良姜（Linn.）、生姜（）、姜黄（Roxb.）、酸橙（）、青柠（DC.）、甜罗勒（Linn.）、毛罗勒（）、柠檬草（DC.）、丁香（）和肉桂（），针对四种标准菌株，即 、 、 、 以及30株耐多药 （MDR - ）临床分离株。
材料与方法
采用琼脂扩散法、最低抑菌浓度和最低杀菌浓度（MBC）来测定水蒸馏药用植物的杀菌活性。在本研究中，茶树油（）用作阳性对照。
结果
结果表明，从肉桂中提取的挥发油对最常见的人类病原体 、 、 、 具有强大的抗菌活性。大多数挥发油提取物对非发酵菌 效果较差。此外，从肉桂、丁香和毛罗勒中提取的挥发油对MDR - 具有强大的杀菌活性，MBC分别为0.5、1和2 mg/mL。
结论
挥发油提取物可作为治疗最常见人类病原体和MDR - 感染的替代天然产物。
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