Cantrill H L, Henry K, Jackson B, Erice A, Ussery F M, Balfour H H
Department of Ophthalmology, University of Minnesota School of Medicine, Minneapolis.
Ophthalmology. 1988 Oct;95(10):1458-62. doi: 10.1016/s0161-6420(88)33011-3.
Human immunodeficiency virus (HIV) was recovered from multiple ocular tissues in three patients with acquired immune deficiency syndrome (AIDS). Consistently found in the retina, HIV was also detected in the conjunctiva, cornea, and iris. In two cases, HIV was detectable despite treatment with oral zidovudine. All three patients had bilateral cytomegalovirus (CMV) retinitis managed by intravitreal injection of ganciclovir. Culture of the retina for CMV was negative in all three cases. The finding of HIV in multiple ocular tissues is consistent with the neurotropic nature of the virus, and may explain some of the common ocular manifestations of AIDS such as AIDS retinopathy. Infection with HIV may predispose the retina to other opportunistic infections and may explain the high incidence of CMV retinitis in AIDS patients. This is the first report of HIV isolation from tissue within the eye.
在三名获得性免疫缺陷综合征（AIDS）患者的多个眼部组织中分离出了人类免疫缺陷病毒（HIV）。HIV一直存在于视网膜中，在结膜、角膜和虹膜中也检测到了该病毒。在两例患者中，尽管接受了口服齐多夫定治疗，仍可检测到HIV。所有三名患者均通过玻璃体内注射更昔洛韦来治疗双侧巨细胞病毒（CMV）视网膜炎。所有三例患者的视网膜CMV培养均为阴性。在多个眼部组织中发现HIV与该病毒的嗜神经性相符，并且可能解释了AIDS的一些常见眼部表现，如AIDS视网膜病变。HIV感染可能使视网膜易患其他机会性感染，并可能解释了AIDS患者中CMV视网膜炎的高发病率。这是首次从眼内组织中分离出HIV的报告。
