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来自野生草莓（Fragaria vesca L.）两种新苄基衍生物的抗抑郁作用 林德利变种 胡克.f.

Antidepressent Effect of Two New Benzyl Derivatives from Wild Strawberry var. Lindl. ex Hook.f.

作者信息

Naz Sadia, Farooq Umar, Khan Ajmal, Khan Haroon, Karim Nasiara, Sarwar Rizwana, Hussain Javid, Rauf Abdur

机构信息

Department of Chemistry, COMSATS Institute of Information TechnologyAbbottabad, Pakistan.

UoN Chair of Oman Medicinal Plants and Marine Products, University of NizwaNizwa, Oman.

出版信息

Front Pharmacol. 2017 Jul 25;8:469. doi: 10.3389/fphar.2017.00469. eCollection 2017.

DOI:10.3389/fphar.2017.00469
PMID:28790915
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5524885/
Abstract

Two new benzyl derivatives were isolated from ethyl acetate fraction of wild strawberry, var. Lindl. ex Hook.f. The structures of these compounds were elucidated to be 5-(4-hydroxy-3-methoxyphenethyl)-7-methoxy-2H-chromen-3-ol () and 5-(4-hydroxy-3-methoxyphenethyl)-4,7-dimethoxy-2H-chromen-3-ol () based on spectroscopic data through IR, UV, H-NMR, C-NMR along with two dimensional (2D) techniques HMBC, HMQC, and COSY. Both compounds and were studied in tail suspension and forced swim tests for antidepressant like effects. A significant dose dependent antidepressant like effect was observed by causing spontaneous anti-immobility at various test doses upon intraperitoneal administration.

摘要

从野生草莓（Fragaria vesca L. var. Lindl. ex Hook.f.）的乙酸乙酯馏分中分离出两种新的苄基衍生物。基于红外光谱（IR）、紫外光谱（UV）、氢核磁共振（H-NMR）、碳核磁共振（C-NMR）以及二维（2D）技术如异核多键相关谱（HMBC）、异核单量子相干谱（HMQC）和同核相关谱（COSY）的光谱数据，确定这些化合物的结构分别为5-(4-羟基-3-甲氧基苯乙基)-7-甲氧基-2H-色烯-3-醇（）和5-(4-羟基-3-甲氧基苯乙基)-4,7-二甲氧基-2H-色烯-3-醇（）。对化合物和在悬尾试验和强迫游泳试验中进行了抗抑郁样作用研究。腹腔注射后，在不同测试剂量下引起自发的抗不动行为，观察到显著的剂量依赖性抗抑郁样作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/722f/5524885/5a353becbd3b/fphar-08-00469-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/722f/5524885/0229dd11c30f/fphar-08-00469-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/722f/5524885/5a353becbd3b/fphar-08-00469-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/722f/5524885/0229dd11c30f/fphar-08-00469-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/722f/5524885/5a353becbd3b/fphar-08-00469-g002.jpg

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