Minigalieva Ilzira A, Katsnelson Boris A, Panov Vladimir G, Varaksin Anatoly N, Gurvich Vladimir B, Privalova Larisa I, Sutunkova Marina P, Klinova Svetlana V
The Medical Research Center for Prophylaxis and Health Protection in Industrial Workers, Ekaterinburg, 620014, Russia.
Institute of Industrial Ecology, the Urals Branch of the Russian Academy of Sciences, Ekaterinburg, Russia.
Toxicol Rep. 2017 Apr 11;4:194-201. doi: 10.1016/j.toxrep.2017.04.002. eCollection 2017.
Assessment of cumulative health risks associated with the widely observed combined effects of two or more metals and their compounds on the organism has the toxicology of mixtures as its scientific basis although there is no full match between such assessment and this basis while some of the contradictions between them are of a fundamental nature. This state of things may be explained not only by simplifications characteristic of the generally recognized methodology of risk assessment but also by extreme complexity of the theory of combined toxicity, the most essential issues of which are considered by authors on the basis of literary and, mostly, their own previously published data.
评估两种或更多金属及其化合物对生物体广泛观察到的联合效应所带来的累积健康风险，其科学依据是混合物毒理学，尽管这种评估与该依据并不完全匹配，而且它们之间的一些矛盾具有根本性。这种情况不仅可以用公认的风险评估方法所具有的简化特征来解释，还可以用联合毒性理论的极端复杂性来解释，作者们基于文献，主要是他们自己先前发表的数据，考虑了联合毒性理论中最关键的问题。
