Wang Yinjuan, Viennet Céline, Jeudy Adeline, Fanian Ferial, He Li, Humbert Philippe
Engineering and Cutaneous Biology Laboratory, University of Bourgogne Franche-Comté, Besançon, France.
Department of Dermatology, Research and Studies Center on the Integument (CERT), University Hospital, Besançon, France.
J Cosmet Dermatol. 2018 Dec;17(6):1101-1107. doi: 10.1111/jocd.12486. Epub 2018 Jan 22.
Sensitive skin is frequently complaint in dermatology consultation with cutaneous manifestations such as stinging, redness, dryness, and burning sensation that affect the quality of life. Its pathogenesis is mainly related to dysfunction of neurosensory, skin barrier, and also immune activity. The treatment is generally based on continuous and topical therapy by nonirritating complex.
To evaluate the antisensitive function of a new complex cream composed by Yunnan Portulaca oleracea extract, Prinsepia utilis oil, beta-glucan, and sodium hyaluronate extracted from mushroom.
A randomized double-blind and self-control study was conducted on 20 selected volunteers with sensitive skin. Subjects applied the test cream to 1 side of the face, and the control cream (tolerance-extreme cream) to the other side of the face, twice daily over 28 days. Evaluations were performed at baseline and at 28 days. Expert clinical grading of facial skin including dryness, roughness, desquamation, and erythema was assessed. Subject self-assessment questionnaires, digital photography and noninvasive bioinstrumentation of hydration, transepidermal water loss, lipid index, skin texture, and wettability were also included in the study.
Products were well tolerated. For all parameters studied, no significant difference was observed between test and control creams. Results showed that test cream provided a statistically significant improvement in clinical grading scores for dryness, roughness, and erythema at 28 days compared to baseline. In addition, statistically significant improvement of skin hydration and texture parameters (eg, smoothness and roughness) was demonstrated. Volunteers' questionnaire revealed self-perceived benefits consistent with expert visual grading.
This study confirmed the effectiveness and tolerance of the new complex cream in subjects with sensitive skin. The test cream could serve as a daily care moisturizer for face.
敏感性皮肤在皮肤科门诊中较为常见，其皮肤表现如刺痛、发红、干燥和烧灼感等会影响生活质量。其发病机制主要与神经感觉、皮肤屏障功能以及免疫活性异常有关。治疗通常基于使用无刺激性复合物进行持续的局部治疗。
评估一种由云南马齿苋提取物、青刺果油、β-葡聚糖和蘑菇提取的透明质酸钠组成的新型复合乳膏的抗敏感功能。
对20名入选的敏感性皮肤志愿者进行随机双盲自身对照研究。受试者将试验乳膏涂抹于一侧面部，另一侧面部涂抹对照乳膏（极致耐受乳膏），每日两次，共28天。在基线和28天时进行评估。对面部皮肤进行专家临床分级，包括干燥、粗糙、脱屑和红斑情况。研究还包括受试者自我评估问卷、数码摄影以及对皮肤水合作用、经表皮水分流失、脂质指数、皮肤质地和润湿性的无创生物检测。
产品耐受性良好。对于所有研究参数，试验乳膏和对照乳膏之间未观察到显著差异。结果显示，与基线相比，试验乳膏在28天时干燥、粗糙和红斑的临床分级评分有统计学意义的改善。此外，皮肤水合作用和质地参数（如光滑度和粗糙度）有统计学意义的改善。志愿者问卷显示自我感觉的益处与专家视觉分级一致。
本研究证实了新型复合乳膏对敏感性皮肤受试者的有效性和耐受性。试验乳膏可作为面部日常护理保湿剂。
