Han Xuesheng, Beaumont Cody, Stevens Nicole
dōTERRA International, LLC, 389 S. 1300 W., Pleasant Grove, UT 84062, USA.
Biochim Open. 2017 Apr 26;5:1-7. doi: 10.1016/j.biopen.2017.04.001. eCollection 2017 Dec.
Research on the biological effects of essential oils on human skin cells is scarce. In the current study, we primarily explored the biological activities of 10 essential oils (nine single and one blend) in a pre-inflamed human dermal fibroblast system that simulated chronic inflammation. We measured levels of proteins critical for inflammation, immune responses, and tissue-remodeling processes. The nine single oils were distilled from (bergamot), (cilantro), (geranium), (helichrysum), (patchouli), (petitgrain), (sandalwood), (spikenard), and (ylang ylang). The essential oil blend (commercial name Immortelle) is composed of oils from frankincense, Hawaiian sandalwood, lavender, myrrh, helichrysum, and rose. All the studied oils were significantly anti-proliferative against these cells. Furthermore, bergamot, cilantro, and spikenard essential oils primarily inhibited protein molecules related to inflammation, immune responses, and tissue-remodeling processes, suggesting they have anti-inflammatory and wound healing properties. Helichrysum and ylang ylang essential oils, as well as Immortelle primarily inhibited tissue remodeling-related proteins, suggesting a wound healing property. The data are consistent with the results of existing studies examining these oils in other models and suggest that the studied oils may be promising therapeutic candidates. Further research into their biological mechanisms of action is recommended. The differential effects of these essential oils suggest that they exert activities by different mechanisms or pathways, warranting further investigation. The chemical composition of these oils was analyzed using gas chromatography-mass spectrometry.
关于精油对人体皮肤细胞生物效应的研究很少。在本研究中，我们主要在模拟慢性炎症的人皮肤成纤维细胞预炎症系统中探索了10种精油（9种单一精油和1种混合精油）的生物活性。我们测量了对炎症、免疫反应和组织重塑过程至关重要的蛋白质水平。9种单一精油分别从佛手柑、芫荽、天竺葵、蜡菊、广藿香、苦橙叶、檀香、甘松和依兰中提取。混合精油（商品名Immortelle）由乳香、夏威夷檀香、薰衣草、没药、蜡菊和玫瑰的精油组成。所有研究的精油对这些细胞均具有显著的抗增殖作用。此外，佛手柑、芫荽和甘松精油主要抑制与炎症、免疫反应和组织重塑过程相关的蛋白质分子，表明它们具有抗炎和伤口愈合特性。蜡菊和依兰精油以及Immortelle主要抑制与组织重塑相关的蛋白质，表明具有伤口愈合特性。这些数据与现有研究在其他模型中检测这些精油所得结果一致，表明所研究的精油可能是有前景的治疗候选物。建议进一步研究它们的生物作用机制。这些精油的不同作用表明它们通过不同的机制或途径发挥作用，值得进一步研究。使用气相色谱 - 质谱联用仪分析了这些精油的化学成分。
