血管组织工程学：进展、挑战与临床前景。
Vascular Tissue Engineering: Progress, Challenges, and Clinical Promise.
机构信息
Harvard-MIT Program in Health Sciences and Technology, Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Biological Design Center, Department of Biomedical Engineering, Boston University, Boston, MA 02215, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA.
Harvard-MIT Program in Health Sciences and Technology, Institute for Medical Engineering and Science, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Department of Surgery, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.
出版信息
Cell Stem Cell. 2018 Mar 1;22(3):340-354. doi: 10.1016/j.stem.2018.02.009.
Although the clinical demand for bioengineered blood vessels continues to rise, current options for vascular conduits remain limited. The synergistic combination of emerging advances in tissue fabrication and stem cell engineering promises new strategies for engineering autologous blood vessels that recapitulate not only the mechanical properties of native vessels but also their biological function. Here we explore recent bioengineering advances in creating functional blood macro and microvessels, particularly featuring stem cells as a seed source. We also highlight progress in integrating engineered vascular tissues with the host after implantation as well as the exciting pre-clinical and clinical applications of this technology.
尽管临床对生物工程血管的需求持续增长，但目前可用的血管移植物仍然有限。组织制造和干细胞工程方面的新兴进展相结合，有望为工程自体血管提供新策略，这些策略不仅可以重现天然血管的机械性能，还可以重现其生物学功能。在这里，我们探讨了在创建功能性血液大血管和微血管方面的最新生物工程进展，特别是以干细胞作为种子来源。我们还强调了在植入后将工程化血管组织与宿主整合的进展，以及该技术在临床前和临床中的令人兴奋的应用。
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