-从（石蒜科）中分离得到氧化石蒜碱类生物碱。
-oxide alkaloids from (Amaryllidaceae).
机构信息
Group of Natural Products, Faculty of Pharmacy, University of Barcelona, Av. Joan XXIII, 27-31, 08028-Barcelona, Spain.
Department of Chemistry, Federal University of Espírito Santo, Av. Fernando Ferrari 514, 29075-915 Vitoria ES, Brazil.
出版信息
Molecules. 2018 May 26;23(6):1277. doi: 10.3390/molecules23061277.
Natural products play an important role in the development of new drugs. In this context, the Amaryllidaceae alkaloids have attracted considerable attention in view of their unique structural features and various biological activities. In this study, twenty-three alkaloids were identified from by GC-MS and two new structures (augustine -oxide and buphanisine -oxide) were structurally elucidated by NMR. Anti-parasitic and cholinesterase (AChE and BuChE) inhibitory activities of six alkaloids isolated from this species, including the two new compounds, are described herein. None of the alkaloids isolated from gave better results than the reference drugs, so it was possible to conclude that the -oxide group does not increase their therapeutic potential.
天然产物在新药开发中起着重要作用。在这方面，鉴于其独特的结构特征和多种生物活性，石蒜科生物碱受到了相当大的关注。在这项研究中，通过 GC-MS 从 中鉴定出二十三种生物碱，通过 NMR 对两种新结构（奥古斯汀氧化物和布芬辛氧化物）进行了结构阐明。本文描述了从该物种中分离得到的六种生物碱（包括两种新化合物）的抗寄生虫和胆碱酯酶（AChE 和 BuChE）抑制活性。从 中分离得到的生物碱没有一种比参考药物的效果更好，因此可以得出结论，-氧化物基团不会增加它们的治疗潜力。
Zotero 插件