Sousa Sílvia A, Seixas António M M, Leitão Jorge H
IBB-Institute for Biotechnology and Biosciences, Department of Bioengineering, Instituto Superior Técnico, Universidade de Lisboa, 1049-001 Lisboa, Portugal.
Vaccines (Basel). 2018 Jun 8;6(2):34. doi: 10.3390/vaccines6020034.
Bacteria of the complex (Bcc) remain an important cause of morbidity and mortality among patients suffering from cystic fibrosis. Eradication of these pathogens by antimicrobial therapy often fails, highlighting the need to develop novel strategies to eradicate infections. Vaccines are attractive since they can confer protection to particularly vulnerable patients, as is the case of cystic fibrosis patients. Several studies have identified specific virulence factors and proteins as potential subunit vaccine candidates. So far, no vaccine is available to protect from Bcc infections. In the present work, we review the most promising postgenomic approaches and selected web tools available to speed up the identification of immunogenic proteins with the potential of conferring protection against Bcc infections.
复合群细菌（Bcc）仍是囊性纤维化患者发病和死亡的重要原因。通过抗菌治疗根除这些病原体的尝试常常失败，这凸显了开发新策略以根除感染的必要性。疫苗具有吸引力，因为它们可以为特别易感染的患者（如囊性纤维化患者）提供保护。多项研究已确定特定的毒力因子和蛋白质作为潜在的亚单位疫苗候选物。到目前为止，尚无预防Bcc感染的疫苗。在本研究中，我们综述了最有前景的后基因组学方法以及一些选定的网络工具，这些工具可用于加速鉴定具有预防Bcc感染潜力的免疫原性蛋白质。
