正常受试者平滑肌抗体与核抗体的相关性
Correlation of smooth-muscle and nuclear antibodies in normal subjects.
作者信息
Andersen P
出版信息
Clin Exp Immunol. 1977 Jan;27(1):74-7.
By means of the indirect immunofluorescent method the occurrence of smooth-muscle antibodies (SMA) was studied in 582 normal subjects of different ages, and the incidence of SMA was compared with that of anti-nuclear antibodies (ANA). SMA were detected in 32 (5-5%) and ANA in 28 (4-8%) of the normal subjects. The antibodies were of the IgG and the IgM class, while no IgA antibodies could be detected. IgM-SMA were demonstrated in 2-9%, IgM-ANA in 4-1% and IgG-ANA in 1-2% of the 582 subjects, and the incidence of these antibodies increased with increasing age (P = 0-012, P less than 0-001 and P = 0-003, respectively). IgG-SMA occurred in 3-6% and the prevalence of these antibodies was not age-related. No relationship between the incidence of antibodies and sex could be established. IgM-SMA and IgM-ANA were often found together in the same individuals (P = 0-002), which suggests that the same factors may elicit the formation of both antibodies.
采用间接免疫荧光法对582名不同年龄的正常受试者进行平滑肌抗体（SMA）检测，并将SMA的发生率与抗核抗体（ANA）的发生率进行比较。在32名（5.5%）正常受试者中检测到SMA，在28名（4.8%）中检测到ANA。这些抗体属于IgG和IgM类，未检测到IgA抗体。在582名受试者中，IgM-SMA的检出率为2.9%，IgM-ANA为4.1%，IgG-ANA为1.2%，且这些抗体的发生率随年龄增长而升高（P分别为0.012、P<0.001和P = 0.003）。IgG-SMA的发生率为3.6%，其患病率与年龄无关。未发现抗体发生率与性别之间存在关联。IgM-SMA和IgM-ANA常同时出现在同一个体中（P = 0.002），这表明相同因素可能引发这两种抗体的形成。
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