Department of Gynecological Oncology, Zhongnan Hospital of Wuhan University, Hubei Cancer Clinical Study Center, Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, Hubei, China.
Karnali Academy of Health Sciences, Jumla, Nepal.
Sci Rep. 2018 Aug 10;8(1):11993. doi: 10.1038/s41598-018-30506-6.
We aimed to assess the quality of life (QOL) of the patients with cervical cancer after initial treatment, the factors affecting QOL and their clinical relevance. A total of 256 patients with cervical cancer who visited Zhongnan Hospital of Wuhan University from January 2017 to December 2017 were enrolled in this study. The European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core-30 item (EORTC QLQ-C30) and cervical cancer module (EORTC QLQ-CX24) was used to assess the QOL of patients. More than half of the patients with cervical cancer reported an excellent QOL. Symptoms mostly experienced were insomnia, constipation, financial difficulties, and menopausal symptoms. Global QOL and social functioning were statistically associated with education level, occupation, the area of living, family income and treatment modality. Similarly, role functioning showed significant association with the stage of cancer, treatment modality and time since diagnosis. The rural area of living and poor economic status of the patients with cervical cancer has a negative impact on overall quality of life. Younger and educated patients are more worried about sexuality. Patients treated with multiple therapies had more problems with their QOL scales than patients treated with surgery only.
我们旨在评估初始治疗后宫颈癌患者的生活质量（QOL）、影响 QOL 的因素及其临床相关性。本研究纳入了 2017 年 1 月至 12 月期间在武汉大学中南医院就诊的 256 例宫颈癌患者。采用欧洲癌症研究与治疗组织生活质量问卷核心 30 项（EORTC QLQ-C30）和宫颈癌模块（EORTC QLQ-CX24）评估患者的 QOL。超过一半的宫颈癌患者报告了极好的 QOL。最常出现的症状是失眠、便秘、经济困难和更年期症状。全球 QOL 和社会功能与教育水平、职业、居住区域、家庭收入和治疗方式统计学相关。同样，角色功能与癌症分期、治疗方式和诊断后时间显著相关。农村地区的生活和宫颈癌患者较差的经济状况对整体生活质量有负面影响。年轻和受过教育的患者对性更担忧。接受多种治疗的患者在 QOL 量表上的问题比仅接受手术治疗的患者更多。
