Department of Screening and Metabolic Diagnostics, Institute of Mother and Child, Kasprzaka 17A, 01-211 Warsaw, Poland.
Department of Nutrition, Institute of Mother and Child, Kasprzaka 17A, 01-211 Warsaw, Poland.
Nutrients. 2018 Sep 6;10(9):1241. doi: 10.3390/nu10091241.
Adipose tissue is a highly active endocrine organ that secrets many pro-inflammatory as well anti-inflammatory adipokines. The aim of the study was to assess serum adipokine profile in prepubertal vegetarian and omnivorous children. Sixty-two children on a vegetarian diet and fifty-five children on an omnivorous diet, aged 5 to 10 years, were studied. Dietary assessment was performed using a nutritional software program. Body composition was measured by dual-energy X-ray absorptiometry. Serum concentrations of adipokines: leptin, soluble leptin receptor (sOB-R), adiponectin (total and high molecular weight), resistin, visfatin, vaspin, and omentin were determined by immunoenzymatic assays. Both studied groups of children were comparable in terms of age, weight, height, body mass index, and body composition. Vegetarians had a lower ( = 0.017) leptin/sOB-R ratio and lower serum concentrations of resistin ( = 0.051), compared with omnivores. Average levels of other adipokines did not differ between both groups of children. However, we observed significantly higher ratios of anti-inflammatory to pro-inflammatory adipokines: adiponectin/leptin 0.70 (0.37⁻0.93) vs 0.39 (0.28⁻0.74), = 0.005, and omentin/leptin 0.40 (0.23⁻0.83) vs. 0.33 (0.15⁻0.48), = 0.011 in vegetarians compared with omnivores. A well-planned vegetarian diet might beneficially affect the adipokine profile and inflammatory status expressed by the ratios of anti-inflammatory to pro-inflammatory adipokines in prepubertal children.
脂肪组织是一种高度活跃的内分泌器官，它分泌许多促炎和抗炎的脂肪因子。本研究旨在评估青春期前素食和杂食儿童的血清脂肪因子谱。研究了 62 名素食儿童和 55 名杂食儿童，年龄 5 至 10 岁。使用营养软件程序进行饮食评估。使用双能 X 射线吸收法测量身体成分。通过免疫酶联测定法测定血清脂肪因子：瘦素、可溶性瘦素受体（sOB-R）、脂联素（总和高分子量）、抵抗素、内脏脂肪素、vaspin 和网膜素。研究中的两组儿童在年龄、体重、身高、体重指数和身体成分方面具有可比性。与杂食者相比，素食者的瘦素/sOB-R 比值较低（ = 0.017），抵抗素血清浓度较低（ = 0.051）。两组儿童的其他脂肪因子平均水平无差异。然而，我们观察到抗炎性与促炎性脂肪因子的比值明显更高：脂联素/瘦素 0.70（0.37⁻0.93）与 0.39（0.28⁻0.74）， = 0.005，以及网膜素/瘦素 0.40（0.23⁻0.83）与 0.33（0.15⁻0.48）， = 0.011，素食者高于杂食者。精心计划的素食饮食可能有益于青春期前儿童的脂肪因子谱和炎症状态，表现为抗炎性与促炎性脂肪因子的比值。
