Vahlsing Thorsten, Delbeck Sven, Leonhardt Steffen, Heise H Michael
1 Bundesanstalt für Materialforschung und -prüfung (BAM), Acoustic and Electromagnetic Methods, Berlin, Germany.
2 Chair for Medical Information Technology, Helmholtz Institute for Biomedical Engineering, RWTH Aachen University, Aachen, Germany.
J Diabetes Sci Technol. 2018 Nov;12(6):1169-1177. doi: 10.1177/1932296818798347. Epub 2018 Sep 15.
Noninvasive blood glucose assays have been promised for many years and various molecular spectroscopy-based methods of skin are candidates for achieving this goal. Due to the small spectral signatures of the glucose used for direct physical detection, moreover hidden among a largely variable background, broad spectral intervals are usually required to provide the mandatory analytical selectivity, but no such device has so far reached the accuracy that is required for self-monitoring of blood glucose (SMBG). A recently presented device as described in this journal, based on photoplethysmographic fingertip images for measuring glucose in a nonspecific indirect manner, is especially evaluated for providing reliable blood glucose concentration predictions.
无创血糖检测技术已被期待多年，基于皮肤的各种分子光谱方法有望实现这一目标。此外，由于用于直接物理检测的葡萄糖的光谱特征较小，且隐藏在变化很大的背景中，通常需要较宽的光谱区间来提供必要的分析选择性，但到目前为止，还没有这样的设备达到自我血糖监测（SMBG）所需的精度。最近在本杂志上介绍的一种设备，基于光电容积脉搏波指尖图像以非特异性间接方式测量葡萄糖，特别评估了其提供可靠血糖浓度预测的能力。
