Dall'Oglio Federica, Milani Massimo, Micali Giuseppe
Dermatology Clinic, University of Catania, Catania, Italy.
Medical Department, Cantabria Labs Difa Cooper, Caronno Pertusella (VA), Italy,
Clin Cosmet Investig Dermatol. 2018 Oct 8;11:445-449. doi: 10.2147/CCID.S179627. eCollection 2018.
We evaluated the effects of 3-month prebiotic oral supplementation with fructo-oligosaccharides (FOS) and galacto-oligosaccharides (GOS) on glucose and lipid metabolic parameters in women with adult acne (female adult acne).
Twelve women, mean age 35 years, with mild to moderate acne were enrolled. Exclusion criteria were severe acne, body mass index (BMI) >25, history of diabetes mellitus, polycystic ovary syndrome, regular intake of prebiotics or probiotics, and history of inflammatory intestinal diseases. At baseline visit (T0), at month 1 (T1), and at month 3 (T2) fasting glucose, blood insulin, glycated hemoglobin (HbA1c), C-peptide, triglycerides, total cholesterol levels, and BMI were measured. Subjects were treated with a food supplement containing FOS (100 mg) and GOS (500 mg), one sachet daily, for 3 months. Subjects were instructed to follow their regular diet, and no dietary restrictions were suggested.
At baseline, the BMI, mean ± SD, was 23±0.7. No modification of BMI was observed during the study. At baseline, fasting blood glucose levels were 92±7 mg/dL. A significant (=0.02) reduction was observed at month 1 (86±5 mg/dL) and at month 3 (85±7 mg/dL) (-10%). Total cholesterol levels were reduced significantly (=0.018) from 184±19 to 161±10 mg/dL (-13%) at the end of the study. Triglycerides at baseline were 51 mg/dL and were reduced to 46 mg/dL (=0.05). Insulin and C-peptide plasma levels showed a nonsignificant reduction trend from baseline to the end of the study. In subjects with baseline insulin level >6 µUI/mL (n=6) the FOS/GOS supplementation induced a significant (=0.03) reduction from 7.8 to 4.3 µUI/mL at day 90 (-45%). C-peptide was reduced from 2.1 to 1.6 ng/mL (month 3). HbA1c at baseline was 35 mg/dL and 32 mg/dL at the end of the study (NS).
In adult female acne, supplementation with prebiotic FOS and GOS was associated with positive effects on glycemic and lipid metabolic parameters.
我们评估了为期3个月口服低聚果糖（FOS）和低聚半乳糖（GOS）益生元对成年女性痤疮患者（成年女性痤疮）血糖和脂质代谢参数的影响。
招募了12名平均年龄35岁、患有轻至中度痤疮的女性。排除标准包括重度痤疮、体重指数（BMI）>25、糖尿病史、多囊卵巢综合征、经常摄入益生元或益生菌以及炎症性肠病病史。在基线访视（T0）、第1个月（T1）和第3个月（T2）测量空腹血糖、血胰岛素、糖化血红蛋白（HbA1c）、C肽、甘油三酯、总胆固醇水平和BMI。受试者接受含FOS（100毫克）和GOS（500毫克）的食品补充剂治疗，每天1包，共3个月。受试者被要求遵循常规饮食，未建议进行饮食限制。
基线时，BMI（平均值±标准差）为23±0.7。研究期间未观察到BMI的变化。基线时，空腹血糖水平为92±7毫克/分升。在第1个月（86±5毫克/分升）和第3个月（85±7毫克/分升）观察到显著（=0.02）降低（-10%）。研究结束时，总胆固醇水平从184±19显著降低（=0.018）至161±10毫克/分升（-13%）。基线时甘油三酯为51毫克/分升，降至46毫克/分升（=0.05）。从基线到研究结束，胰岛素和C肽血浆水平呈非显著降低趋势。在基线胰岛素水平>6微国际单位/毫升的受试者（n = 6）中，FOS/GOS补充剂在第90天导致从7.8显著降低（=0.03）至4.3微国际单位/毫升（-45%）。C肽从2.1降至1.6纳克/毫升（第3个月）。基线时HbA1c为35毫克/分升，研究结束时为32毫克/分升（无显著性差异）。
在成年女性痤疮患者中，补充益生元FOS和GOS对血糖和脂质代谢参数有积极影响。
