Lew A M, Anders R F, Edwards S J, Langford C J
Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Victoria, Australia.
Immunology. 1988 Oct;65(2):311-4.
The immunogenicity of a malaria peptide presented in various forms was tested in terms of the quality and quantity of the antibody response in rabbits. Peptide conjugated to a protein carrier, diphtheria toxoid (DT), required strong adjuvants (e.g. muramyl dipeptide, MDP and Freund's adjuvant, FCA) to elicit high levels of antibody with high avidity. Alum was a poor adjuvant, producing the lowest titre and avidity of antibody compared with all the other groups. Peptide expressed in vaccinia (and without carrier) produced intermediate levels of antibody but the avidity of the antibodies produced were comparable to that produced by peptide conjugates given with muramyl dipeptide.
根据兔体内抗体反应的质量和数量，对以各种形式呈现的疟疾肽的免疫原性进行了测试。与蛋白质载体白喉类毒素（DT）偶联的肽，需要强效佐剂（如胞壁酰二肽、MDP和弗氏佐剂、FCA）才能引发高亲和力的高水平抗体。明矾是一种较差的佐剂，与所有其他组相比，产生的抗体滴度和亲和力最低。痘苗中表达的（无载体）肽产生中等水平的抗体，但所产生抗体的亲和力与用胞壁酰二肽给予的肽偶联物所产生的相当。
