Behavioral Science Institute, Radboud University, Nijmegen, The Netherlands.
Department of Cognitive Neuroscience, Donders Institute for Brain, Cognition and Behaviour, Radboud University Medical Center, Nijmegen, The Netherlands.
Dev Psychobiol. 2019 Jul;61(5):772-782. doi: 10.1002/dev.21824. Epub 2019 Jan 14.
Fostering healthy developmental growth in the first years of life is associated with numerous favorable cognitive, social, and economic outcomes. Funding and promoting research aimed at identifying potential targets for early intervention should be a top priority for lawmakers and funders. One promising avenue of research and potential early intervention is the microbiota-gut-brain axis. In this report, we briefly examine the role of the gut microbiota in human life, focusing on links with health, cognition, and behavior. We then discuss the development of the gut microbiota and the critical early window in which colonization occurs. Then, we review current nonnutritive means of influencing the gut microbiota in early life. Finally, we discuss the implications this work has for early intervention in low-income communities and end with recommendations regarding further research and research funding priorities.
促进生命早期的健康发育与许多有利的认知、社会和经济结果相关。为识别早期干预的潜在目标而提供资金并促进研究应该成为立法者和资助者的首要任务。一个有前途的研究和潜在的早期干预途径是微生物群-肠道-大脑轴。在本报告中，我们简要检查了肠道微生物群在人类生活中的作用，重点关注与健康、认知和行为的联系。然后，我们讨论了肠道微生物群的发展和定植发生的关键早期窗口。接下来，我们回顾了目前在生命早期影响肠道微生物群的非营养手段。最后，我们讨论了这项工作对低收入社区早期干预的意义，并提出了关于进一步研究和研究资金优先事项的建议。
