Department of Preventive Dentistry, Academic Centre for Dentistry Amsterdam (ACTA), University of Amsterdam and VU University Amsterdam, G. Mahlerlaan 3004, 1081 LA, Amsterdam, The Netherlands.
Odontology. 2019 Oct;107(4):437-448. doi: 10.1007/s10266-019-00413-x. Epub 2019 Feb 4.
The indivisible relationship between the human host and its oral microbiome has been shaped throughout the millennia, by facing various changes that have forced the adaptation of oral microorganisms to new environmental conditions. In this constant crosstalk between the human host and its microbiome, a bidirectional relationship has been established. The microorganisms provide the host with functions it cannot perform on its own and at the same time the host provides its microbes with a suitable environment for their growth and development. These host factors can positively affect the microbiome, promoting diversity and balance between different species, resulting in a state of symbiosis and absence of pathology. In contrast, other host factors can negatively influence the composition of the oral microbiome and drive the interaction towards a dysbiotic state, where the balance tilts towards a harmful relationship between the host and its microbiome. The aim of this review is to describe the role host factors play in cultivating and maintaining a healthy oral ecology and discuss mechanisms that can prevent its drift towards dysbiosis.
人类宿主与其口腔微生物组之间不可分割的关系，是通过应对各种变化而形成的，这些变化迫使口腔微生物适应新的环境条件。在人类宿主与其微生物组之间的这种持续交流中，建立了一种双向关系。微生物为宿主提供了其自身无法完成的功能，而宿主同时为其微生物提供了适宜的生长和发育环境。这些宿主因素可以积极影响微生物组，促进不同物种之间的多样性和平衡，从而达到共生和无病状态。相比之下，其他宿主因素可能会对口腔微生物组的组成产生负面影响，并促使相互作用向失调状态发展，在这种状态下，宿主与其微生物组之间的平衡倾向于产生有害关系。本综述旨在描述宿主因素在培养和维持健康口腔生态系统中的作用，并讨论可以防止其向失调状态漂移的机制。
