妊娠肝内胆汁淤积症患者血清硒浓度及谷胱甘肽过氧化物酶活性降低。
Low serum selenium concentration and glutathione peroxidase activity in intrahepatic cholestasis of pregnancy.
作者信息
Kauppila A, Korpela H, Mäkilä U M, Yrjänheikki E
出版信息
Br Med J (Clin Res Ed). 1987 Jan 17;294(6565):150-2. doi: 10.1136/bmj.294.6565.150.
Abstract
Serum selenium concentrations were found to be significantly lower in women with intrahepatic cholestasis of pregnancy than in women with normal pregnancies during the last trimester of pregnancy and post partum. The activity of the selenoenzyme glutathione peroxidase had a significant positive correlation with selenium concentration and it was also significantly lower in women with the disease. These findings suggest that selenium deficiency and reduced glutathione peroxidase activity are associated with the aetiopathogenesis of intrahepatic cholestasis of pregnancy.
摘要
研究发现，妊娠肝内胆汁淤积症女性在妊娠晚期及产后血清硒浓度显著低于正常妊娠女性。硒酶谷胱甘肽过氧化物酶的活性与硒浓度呈显著正相关，且该疾病女性的该酶活性也显著降低。这些发现表明，硒缺乏和谷胱甘肽过氧化物酶活性降低与妊娠肝内胆汁淤积症的病因发病机制有关。
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