表面等离子体共振显微镜：从单分子传感到单细胞成像
Surface Plasmon Resonance Microscopy: From Single-Molecule Sensing to Single-Cell Imaging.
作者信息
Zhou Xiao-Li, Yang Yunze, Wang Shaopeng, Liu Xian-Wei
机构信息
CAS Key Laboratory of Urban Pollutant Conversion, Department of Applied Chemistry, University of Science & Technology of China, Hefei, 230026, China.
Center for Biosensors and Bioelectronics, Biodesign Institute, Arizona State University, Tempe, AZ, 85287, USA.
出版信息
Angew Chem Int Ed Engl. 2020 Jan 27;59(5):1776-1785. doi: 10.1002/anie.201908806. Epub 2019 Oct 18.
Abstract
Surface plasmon resonance microscopy (SPRM) is a versatile platform for chemical and biological sensing and imaging. Great progress in exploring its applications, ranging from single-molecule sensing to single-cell imaging, has been made. In this Minireview, we introduce the principles and instrumentation of SPRM. We also summarize the broad and exciting applications of SPRM to the analysis of single entities. Finally, we discuss the challenges and limitations associated with SPRM and potential solutions.
摘要
表面等离子体共振显微镜（SPRM）是一种用于化学和生物传感及成像的多功能平台。在探索其应用方面已取得了巨大进展，涵盖从单分子传感到单细胞成像等领域。在这篇微型综述中，我们介绍了SPRM的原理和仪器设备。我们还总结了SPRM在单个实体分析方面广泛且令人兴奋的应用。最后，我们讨论了与SPRM相关的挑战和局限性以及潜在的解决方案。
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