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叶提取物对……的生长抑制活性

Growth Inhibitory Activity of Leaf Extracts Against .

作者信息

Pineau Rozenn M, Hanson Sarah E, Lyles James T, Quave Cassandra L

机构信息

School of Biological Sciences, Georgia Institute of Technology, Atlanta, GA, United States.

Center for the Study of Human Health, Emory College of Arts and Sciences, Atlanta, GA, United States.

出版信息

Front Pharmacol. 2019 Oct 15;10:1206. doi: 10.3389/fphar.2019.01206. eCollection 2019.

DOI:10.3389/fphar.2019.01206
PMID:31680977
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6803531/
Abstract

Acne vulgaris is a common skin disease affecting adolescents and young adults of all ethnic groups, negatively impacting self-esteem, self-confidence, and social life. The Gram-positive bacteria colonizes the sebum-rich follicle and contributes to inflammation of the pilosebaceous gland. Long-term antibiotic therapies targeting lead to the development of antimicrobial resistance, and novel acne vulgaris therapies are needed. This study investigated the inhibitory activity of leaves, a native Southeastern United States shrub historically used by Native Americans to treat fever, stomachache, and pruritis. Flash chromatography fractions of the ethyl acetate-soluble ethanol leaf extract (649C-F9 and 649C-F13) exhibited MICs ranging from 16 to 32 µg ml and IC range of 4-32 μg ml against a panel of 10 distinct isolates. Cytotoxicity against an immortalized human keratinocyte cell line (HaCaTs) skin was detected at more than eight times the dose required for growth inhibitory activity (IC of 256 μg ml for 649C-F9 and IC of >512 μg ml for 649C-F13). This work highlights the potential of leaf extracts as a cosmeceutical ingredient for the management of acne vulgaris. Further research is necessary to assess its mechanism of action and efficacy.

摘要

寻常痤疮是一种常见的皮肤病，影响着所有种族的青少年和年轻人，对自尊、自信和社交生活产生负面影响。革兰氏阳性菌定植于富含皮脂的毛囊，并导致皮脂腺炎症。针对该菌的长期抗生素治疗会导致抗菌耐药性的产生，因此需要新的寻常痤疮治疗方法。本研究调查了一种美国东南部本土灌木的叶子的抑制活性，这种灌木在历史上被美洲原住民用于治疗发烧、胃痛和瘙痒。乙酸乙酯可溶的乙醇叶提取物的快速色谱馏分（649C-F9和649C-F13）对一组10种不同的分离株表现出16至32μg/ml的最低抑菌浓度（MIC）和4至32μg/ml的IC范围。在对永生化人角质形成细胞系（HaCaTs）皮肤的细胞毒性检测中，生长抑制活性所需剂量的八倍以上时才检测到细胞毒性（649C-F9的IC为256μg/ml，649C-F13的IC>512μg/ml）。这项工作突出了该植物叶提取物作为一种用于治疗寻常痤疮的药妆成分的潜力。有必要进一步研究以评估其作用机制和疗效。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63a4/6803531/30cdc7d2ab10/fphar-10-01206-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63a4/6803531/851cb114e566/fphar-10-01206-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63a4/6803531/54bb55ba9201/fphar-10-01206-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63a4/6803531/d4686d0b9ef1/fphar-10-01206-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63a4/6803531/6d13af1cb31a/fphar-10-01206-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63a4/6803531/a33d71377295/fphar-10-01206-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63a4/6803531/ece8ba4fd197/fphar-10-01206-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63a4/6803531/30cdc7d2ab10/fphar-10-01206-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63a4/6803531/851cb114e566/fphar-10-01206-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63a4/6803531/54bb55ba9201/fphar-10-01206-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63a4/6803531/d4686d0b9ef1/fphar-10-01206-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63a4/6803531/6d13af1cb31a/fphar-10-01206-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63a4/6803531/a33d71377295/fphar-10-01206-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63a4/6803531/ece8ba4fd197/fphar-10-01206-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/63a4/6803531/30cdc7d2ab10/fphar-10-01206-g007.jpg

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