performance of plasma-sprayed CaO-MgO-SiO-based bioactive glass-ceramic coating on Ti-6Al-4V alloy for bone regeneration.

The CaO-MgO-SiO-based bioactive glass-ceramic coating (named M2) on Ti-6Al-4V alloy has been proven to behave well . But how to make full sense of its performances in terms of osteogenesis and osseointegration matters very much. For this, the M2-coated Ti-6Al-4V cylinders were prepared by atmospheric plasma spraying (APS) and implanted into New Zealand rabbit for 1, 2 and 3 months, respectively, by setting commercial HA-coated Ti-6Al-4V as the control. It is encouraging that, the two groups bonded with the surrounding tissues stably and newly formed bone grew towards or around the implants after 3-month implantation according to radiographic images. From the histological sections, it is obvious that, compared to the control, the M2-coated implant was more favorable for the osteogenesis and neo- in the whole experimental process and demonstrated a better osseointegration with the host bone, indicating the former possessed better osteoconductivity, osteoinductivity and osteogenic ability. The study indicated that the M2-coated Ti-6Al-4V implant exerted a great potential to substitute the commercial HA-coated Ti-6Al-4V implant in repairing load-bearing bone defects.