Institute of General Practice, Ulm University, Helmholtzstr. 20, 89081 Ulm, Germany.
Institute of Medical Informatics, Georg-August University, Von-Siebold-Str. 3, 37075 Göttingen, Germany.
Nutrients. 2019 Nov 21;11(12):2854. doi: 10.3390/nu11122854.
The epidemic of lifestyle-dependent diseases and the failure of previous interventions to combat the main causes demand an alternative approach. Abdominal obesity is associated with most of these diseases and is a good target for therapeutic and preventive measures. Time-restricted feeding (TRF) offers a low-threshold, easy-to-implement lifestyle-modification concept with promising results from animal testing. Here, we describe a pilot study of TRF with abdominally obese participants (waist-to-height ratio, WHtR ≥0.5) in a general practitioner's office. Participants ( = 40, aged 49.1 ± 12.4, 31 females) were asked to restrict their daily eating time to 8-9 hours in order to prolong their overnight fasting period to 15-16 hours. Questionnaires, anthropometrics, and blood samples were used at baseline and at follow-up. After three months of TRF, participants had reached the fasting target, on average, on 85.5 ± 15.2% of all days recorded. Waist circumference (WC) was reduced by -5.3 ± 3.1cm ( < 0.001), and three participants reached a WHtR <0.5. HbA1c was diminished by -1.4 ± 3.5 mmol/mol ( = 0.003). TRF may be an easily understandable and readily adoptable lifestyle change with the potential to reduce abdominal obesity and lower the risk for cardiometabolic diseases. Further well-designed studies are necessary to investigate the applicability and usefulness of TRF for public health.
生活方式相关疾病的流行以及先前对抗主要病因的干预措施的失败，都要求我们采取替代方法。腹部肥胖与大多数这些疾病都有关联，是治疗和预防措施的一个很好的靶点。限时进食（TRF）提供了一种低门槛、易于实施的生活方式改变概念，并且在动物试验中取得了有前景的结果。在这里，我们描述了一项在普通科医生办公室中针对腹部肥胖参与者（腰围与身高比，WHtR≥0.5）进行的限时进食的初步研究。要求参与者将每日进食时间限制在 8-9 小时内，以延长夜间禁食期至 15-16 小时。在基线和随访时使用问卷、人体测量学和血液样本。在进行限时进食三个月后，参与者平均在记录的所有天数的 85.5±15.2%达到了禁食目标。腰围（WC）减少了-5.3±3.1cm（<0.001），有三名参与者的 WHtR 降到了<0.5。HbA1c 降低了-1.4±3.5mmol/mol（=0.003）。TRF 可能是一种易于理解和易于采用的生活方式改变，具有减轻腹部肥胖和降低心血管代谢疾病风险的潜力。需要进一步进行精心设计的研究，以调查 TRF 对公共卫生的适用性和有用性。
