Mahmoud Usama T, Abdel-Mohsein Hosnia S, Mahmoud Manal A M, Amen Omar A, Hassan Rasha I M, Abd-El-Malek Ashraf M, Rageb Sohair M M, Waly Hanan S A, Othman Aly A, Osman Mohamed A
Department of Animal and Poultry Behaviour and Management, Faculty of Veterinary Medicine, Assiut University, Assiut, 71526, Egypt.
Department of Animal Hygiene, Faculty of Veterinary Medicine, Assiut University, Assiut, 71526, Egypt.
Trop Anim Health Prod. 2020 Jul;52(4):2043-2054. doi: 10.1007/s11250-020-02229-2. Epub 2020 Feb 3.
The current study investigated the effects of zinc oxide nanoparticles (ZONPs) and oxytetracycline (OTC) supplementation on broilers' behavior, performance, carcass quality, biochemical parameters, and intestinal microbial populations and birds' response to Newcastle disease (ND) vaccine. A total of 336 seven-day-old IR broiler chicks were randomly allotted to six dietary treatments containing 0, 10, 20, 30 and 40 ppm ZONPs or 50 ppm OTC. Each diet was fed to 7 replicates (8 birds/pen). The results clarified that 10 ppm ZONPs significantly improved the body weight gain and feed conversion in comparison to the control. No changes in behavior were recorded. The 10 ppm and 30 ppm ZONPs and OTC significantly reduced the gizzard weight in comparison to the control. While, 10 ppm ZONPs significantly increased the spleen weight, and all ZONPs doses increased bursa weight in comparison to the control and OTC groups. 20 ppm ZONPs increased the eviscerated yield and edible yield in comparison to the control and OTC groups. 40 ppm ZONPs increased pH, reduced meat color and overall acceptability in comparison to the control. In addition, results revealed that the 20 ppm ZONPs increased Calcium (Ca), High density low cholesterol (HDL-C), reduced urea (UA) and triglyceride (TG). Also, 40 ppm ZONPs and OTC increased creatinine (Cr) and reduced ND-HI titer in comparison to the control. For microbial population, OTC group was significantly lower than ZONPs groups in the total anaerobic, aerobic and lactobacilli count. In conclusion, the dietary inclusion of ZONPs can be applied as antibiotic growth promoter substitutions in broilers' diet. However, further investigations are still needed.
本研究调查了氧化锌纳米颗粒（ZONPs）和土霉素（OTC）添加对肉鸡行为、生产性能、胴体品质、生化参数、肠道微生物种群以及鸡对新城疫（ND）疫苗反应的影响。总共336只7日龄的IR肉鸡雏鸡被随机分配到六种日粮处理组，分别含有0、10、20、30和40 ppm的ZONPs或50 ppm的OTC。每种日粮饲喂7个重复组（每栏8只鸡）。结果表明，与对照组相比，10 ppm的ZONPs显著提高了体重增加和饲料转化率。行为方面未记录到变化。与对照组相比，10 ppm和30 ppm的ZONPs以及OTC显著降低了砂囊重量。同时，与对照组和OTC组相比，10 ppm的ZONPs显著增加了脾脏重量，所有ZONPs剂量均增加了法氏囊重量。与对照组和OTC组相比，20 ppm的ZONPs提高了屠体产量和可食产量。与对照组相比，40 ppm的ZONPs提高了pH值，降低了肉色和总体可接受性。此外，结果显示20 ppm的ZONPs增加了钙（Ca）、高密度低胆固醇（HDL-C），降低了尿素（UA）和甘油三酯（TG）。同样，与对照组相比，40 ppm的ZONPs和OTC增加了肌酐（Cr）并降低了ND-HI效价。对于微生物种群，OTC组的总厌氧菌、需氧菌和乳酸菌计数显著低于ZONPs组。总之，日粮中添加ZONPs可作为肉鸡日粮中抗生素生长促进剂的替代品。然而，仍需要进一步研究。
