Price M J, Drance S M, Price M, Schulzer M, Douglas G R, Tansley B
Department of Ophthalmology, Boston University School of Medicine, Mass.
Graefes Arch Clin Exp Ophthalmol. 1988;226(6):542-7. doi: 10.1007/BF02169202.
The pattern electroretinogram (PERG) may reflect ganglion cell or inner retinal layer activity. The most sensitive spatial and temporal variables for testing patients with glaucoma have not yet been identified. Fifty-two glaucoma suspects, 51 glaucoma patients, and 28 normal subjects were studied with the PERG and VEP, using three repetition rates and three spatial frequencies. Fast Fourier transforms were calculated at each spatial frequency and reversal rate. An analysis of variance revealed that normals could be differentiated from ocular hypertension and glaucoma patients using the amplitude of the PERG (second and fourth harmonic). Abnormalities in phase of the PERG between groups were also detected. A discriminant analysis of all amplitude and phase data revealed that the phase shift of the response of the second harmonic at 11 alternations/s (15-min checks) and at 5.5 alternations/s (15-min checks) correctly identified 81% of the normal and 75% of the glaucoma patients. The phase shift determinations of the VEP revealed significant abnormalities using 2 and 1/2 standard deviation confidence limits. There was significant overlap in the pattern ERG amplitude and phase shift in all three groups.
图形视网膜电图（PERG）可能反映神经节细胞或视网膜内层的活动。用于检测青光眼患者的最敏感的空间和时间变量尚未确定。使用三种重复率和三种空间频率，对52名青光眼疑似患者、51名青光眼患者和28名正常受试者进行了PERG和VEP研究。在每个空间频率和反转率下计算快速傅里叶变换。方差分析显示，使用PERG的振幅（二次谐波和四次谐波）可以将正常人与高眼压症患者和青光眼患者区分开来。还检测到各组之间PERG相位的异常。对所有振幅和相位数据的判别分析显示，在11次交替/秒（15分钟检查）和5.5次交替/秒（15分钟检查）时二次谐波反应的相移正确识别了81%的正常人和75%的青光眼患者。使用2.5个标准差置信限，VEP的相移测定显示出显著异常。三组中图形视网膜电图的振幅和相移存在显著重叠。
