消费白藜芦醇和类黄酮与膳食纤维摄入无关，可降低肥胖风险。
Consumption of Stilbenes and Flavonoids is Linked to Reduced Risk of Obesity Independently of Fiber Intake.
机构信息
Department of Twin Research & Genetic Epidemiology, King's College London, St Thomas' Hospital Campus, Westminster Bridge Road, London SE1 7EH, UK.
Department of Nutritional Sciences, King's College London, Franklin-Wilkins Building, Stamford St, London SE1 9NH, UK.
出版信息
Nutrients. 2020 Jun 23;12(6):1871. doi: 10.3390/nu12061871.
BACKGROUND
Polyphenol consumption is implicated in gut microbiome composition and improved metabolic outcomes, but it is unclear whether the effect is independent of dietary fiber.
METHODS
We investigated the links between (poly)phenol intake, gut microbiome composition (16s RNA) and obesity independently of fiber intake in UK women ( = 1810) and in a small group of UK men ( = 64).
RESULTS
(Poly)phenol intakes correlated with microbiome alpha diversity (Shannon Index) after adjusting for confounders and fiber intake. Moreover, flavonoid intake was significantly correlated with the abundance of , (a genus known to improve physical performance), and stilbene intake with that of butyrate-producing bacteria ( and . Stilbene and flavonoid intake also correlated with lower odds of prevalent obesity ( Odds Ratio (95% Confidence Interval) (OR(95%CI)) = 0.80 (0.73, 0.87), = 4.90 × 10; : OR(95%CI) = 0.77 (0.65, 0.91), = 0.002). Formal mediation analyses revealed that gut microbiome mediates ~11% of the total effect of flavonoid and stilbene intake on prevalent obesity.
CONCLUSIONS
Our findings highlight the importance of (poly)phenol consumption for optimal human health.
背景
多酚的摄入与肠道微生物群组成和改善代谢结果有关，但尚不清楚这种影响是否独立于膳食纤维。
方法
我们调查了英国女性（= 1810）和一小部分英国男性（= 64）中，多酚摄入量与肠道微生物群组成（16s RNA）与肥胖之间的联系，而不考虑膳食纤维的摄入量。
结果
（多）酚类物质的摄入量与调整混杂因素和膳食纤维摄入量后的微生物群多样性（香农指数）相关。此外，黄酮类化合物的摄入量与 的丰度显著相关（已知该菌属可提高身体机能），而白藜芦醇的摄入量与产丁酸菌（ 和 ）的丰度相关。白藜芦醇和黄酮类化合物的摄入量也与普遍肥胖的几率降低相关（优势比（95%置信区间）（OR（95%CI））= 0.80（0.73，0.87），= 4.90×10； ：OR（95%CI）= 0.77（0.65，0.91），= 0.002）。正式的中介分析表明，肠道微生物群介导了黄酮类和白藜芦醇摄入对普遍肥胖的总影响的约 11%。
结论
我们的发现强调了（多）酚类物质摄入对人类健康的重要性。
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