Sanya People's Hospital, Sanya, People's Republic of China.
School of Medical Technology, Baotou Medical College, Baotou, People's Republic of China.
Emerg Microbes Infect. 2020 Dec;9(1):1618-1627. doi: 10.1080/22221751.2020.1788995.
Brucellosis caused by is considered to be one of the most important zoonotic diseases in China. In this study, Conventional bio-typing, MLVA (multiple locus variable-number tandem repeat analysis), and WGS (whole-genome sequencing)-SNP (single nucleotide polymorphism) were used to study the genetic similarity of in northern and southern China and analyze its relationship with worldwide lineages. Currently, the distribution of species/biovars of has obviously changed, and has become the dominant species in southern regions of China. Strains from the southern had a common geographic origin with strains from the northern. Many MLVA-16 events were shared in the genotypes of the southern and northern strains, suggest that genotypic movement occurred from north to south. Based on WGS-SNP analysis, strains from different provinces were closely related and may have descended from one common ancestor, suggests that the southern strains originated from northern China. These data indicate that is a latent "travel bacterium" that spread and expanded from North China to South China. Moreover, strains from China are also genetically related to strains from other Asian regions (Kazakhstan, Russia, Mongolia, and India). The movement of infected sheep and their products requires control.
由引起的布氏杆菌病被认为是中国最重要的人畜共患病之一。在本研究中，采用常规生物分型、MLVA（多位点可变数目串联重复分析）和 WGS（全基因组测序）-SNP（单核苷酸多态性）分析方法，研究了中国南北地区的遗传相似性，并分析了其与世界谱系的关系。目前，的种/生物型分布明显发生了变化，已成为中国南方地区的优势种。南方的菌株与北方的菌株具有共同的地理起源。南方和北方菌株的许多 MLVA-16 事件共享基因型，提示存在从北向南的基因型传播。基于 WGS-SNP 分析，来自不同省份的菌株密切相关，可能起源于一个共同的祖先，提示南方菌株起源于中国北方。这些数据表明，是一种潜在的“旅行菌”，从中国北方传播并扩展到中国南方。此外，中国的菌株与来自其他亚洲地区（哈萨克斯坦、俄罗斯、蒙古和印度）的菌株在遗传上也有关联。感染绵羊及其产品的流动需要加以控制。
