Crivellente Federica, Hart Andy, Hernandez-Jerez Antonio F, Hougaard Bennekou Susanne, Pedersen Ragnor, Terron Andrea, Wolterink Gerrit, Mohimont Luc
EFSA J. 2019 Sep 17;17(9):e05800. doi: 10.2903/j.efsa.2019.5800. eCollection 2019 Sep.
Cumulative assessment groups of pesticides have been established for five effects on the nervous system: brain and/or erythrocyte acetylcholinesterase inhibition, functional alterations of the motor, sensory and autonomic divisions, and histological neuropathological changes in neural tissue. Sources of uncertainties resulting from the methodological approach and from the limitations in available data and scientific knowledge have been identified and considered. This report supports the publication of a scientific report on cumulative risk assessment to pesticides affecting the nervous system, in which all uncertainties identified for either the exposure assessment or the establishment of the cumulative assessment groups are incorporated into a consolidated risk characterisation.
脑和/或红细胞乙酰胆碱酯酶抑制、运动、感觉和自主神经分支的功能改变以及神经组织的组织学神经病理学变化。已确定并考虑了方法学方法以及现有数据和科学知识局限性所导致的不确定性来源。本报告支持发布一份关于影响神经系统农药累积风险评估的科学报告，其中将暴露评估或累积评估组建立过程中确定的所有不确定性纳入综合风险特征描述中。
