Zhang Xiaoli, Pan Zui
Department of Biomedical Informatics, The Ohio State University, Columbus, OH, USA.
College of Nursing and Health Innovation, The University of Texas at Arlington, Arlington, TX, USA.
Gastroenterol Rep (Oxf). 2020 Jun 4;8(3):206-214. doi: 10.1093/gastro/goaa014. eCollection 2020 Jun.
Gastric and esophageal cancers are multifactorial and multistage-involved malignancy. While the impact of gut microbiota on overall human health and diseases has been well documented, the influence of gastric and esophageal microbiota on gastric and esophageal cancers remains unclear. This review will discuss the reported alteration in the composition of gastric and esophageal microbiota in normal and disease conditions, and the potential role of dysbiosis in carcinogenesis and tumorigenesis. This review will also discuss how dysbiosis stimulates local and systemic immunity, which may impact on the immunotherapy for cancer.
胃癌和食管癌是涉及多因素、多阶段的恶性肿瘤。虽然肠道微生物群对人类整体健康和疾病的影响已有充分记载，但胃和食管微生物群对胃癌和食管癌的影响仍不清楚。本综述将讨论在正常和疾病状态下胃和食管微生物群组成的报道性改变，以及生态失调在致癌作用和肿瘤发生中的潜在作用。本综述还将讨论生态失调如何刺激局部和全身免疫，这可能会影响癌症的免疫治疗。
