Alshinnawy Ameera S, El-Sayed Wael M, Taha AlShaimaa M, Sayed Ahmed A, Salem Ahmed M
Department of Biochemistry, Faculty of Science, Ain Shams University, Cairo Egypt.
Department of Zoology, Faculty of Science, Ain Shams University, Cairo Egypt.
Turk J Biol. 2020 Aug 19;44(4):166-175. doi: 10.3906/biy-2001-5. eCollection 2020.
By aging, male fertility and kidney function decline. Therefore, the investigation of health span-extending agents becomes more urgent to overcome aging-induced infertility and kidney dysfunction. The current research was undertaken to investigate the antiaging efficacy of telomerase activator-65 (Ta-65) and pomegranate supplements. Forty male Wistar rats were divided into young rats, aged rats, aged rats treated with Ta-65 (500mg/kg/day), and aged rats treated with pomegranate (250mg/kg/day). Testosterone, FSH, LH, and kidney functions were measured in serum. Sperm analysis as well as testicular histological examination was performed. Aging caused an imbalance in male sex hormones resulting in sperm abnormality and reductions in the sperm count and motility. Elevations in serum creatinine, uric acid, sodium, and potassium were reported in aged rats. Treatment with Ta-65 or pomegranate effectively ameliorated all the deteriorations induced by normal aging in male fertility and renal function. Ta-65 and pomegranate possessed strong antiaging activity by alleviating aging-induced male infertility through reestablishing the hormonal balance and testis architecture. They also alleviated the kidney dysfunction. On comparing Ta-65 with pomegranate, the improvement in FSH, LH, and sperm abnormalities caused by Ta-65 was much better than that caused by pomegranate.
随着年龄增长，男性生育能力和肾功能会下降。因此，对于延长健康寿命的药物进行研究以克服衰老引起的不育和肾功能障碍变得更加迫切。当前的研究旨在探究端粒酶激活剂 - 65（Ta - 65）和石榴补充剂的抗衰老功效。将40只雄性Wistar大鼠分为年轻大鼠组、老年大鼠组、用Ta - 65（500mg/kg/天）治疗的老年大鼠组和用石榴（250mg/kg/天）治疗的老年大鼠组。检测血清中的睾酮、促卵泡激素（FSH）、促黄体生成素（LH）和肾功能。进行精子分析以及睾丸组织学检查。衰老导致男性性激素失衡，从而导致精子异常以及精子数量和活力下降。老年大鼠血清肌酐、尿酸、钠和钾升高。用Ta - 65或石榴治疗可有效改善正常衰老引起的男性生育能力和肾功能的所有恶化情况。Ta - 65和石榴通过重新建立激素平衡和睾丸结构来缓解衰老引起的男性不育，从而具有强大的抗衰老活性。它们还缓解了肾功能障碍。比较Ta - 65和石榴，Ta - 65对FSH、LH和精子异常的改善效果比石榴更好。
