巴西南部一种棕色蜂胶的化学成分及抗支原体活性
Chemical composition and antimycoplasma activity of a brown propolis from southern Brazil.
作者信息
do Nascimento Araújo Camila, Mayworm Marco Aurelio Sivero, Yatsuda Regiane, Negri Giuseppina, Salatino Maria Luiza Faria, Salatino Antonio, Timenetsky Jorge, Campos Guilherme Barreto
机构信息
Universidade Santo Amaro, Rua Prof. Eneas de Siqueira Neto, 340, São Paulo, SP 04829-300 Brazil.
Instituto Multidisciplinar em Saúde, Universidade Federal da Bahia, Campus Anísio Teixeira, Rua Hormindo Barros 58, Vitória da Conquista, BA 45.029-094 Brazil.
出版信息
J Food Sci Technol. 2020 Nov;57(11):4228-4235. doi: 10.1007/s13197-020-04461-y. Epub 2020 Apr 30.
Extracts of a sample of brown propolis produced in the district of Itapará (Southern Brazil) were obtained with solvents with increasing polarity. The extracts were analyzed by RPHPLC-DAD-ESI-MS/MS and evaluated toward activity against , , , , , and . Typical components of "alecrim-do-campo" propolis (e.g. prenylated phenylpropanoids and caffeoyl-quinic acids) were characterized in the analyzed extraccts, in addition to several flavonols. Less polar extracts showed higher anti-mycoplasma activity (MIC value commonly 3.9 μg/mL) than alcoholic and aqueous extracts (MIC value often 7.8-250 μg/mL). The results indicate that Itapará propolis is a promising source for the development of therapeutic drugs.
从巴西南部伊塔帕拉地区生产的棕色蜂胶样品中，用极性递增的溶剂提取提取物。提取物通过反相高效液相色谱-二极管阵列检测-电喷雾电离串联质谱（RPHPLC-DAD-ESI-MS/MS）进行分析，并评估其对[此处原文缺失具体微生物名称]、[此处原文缺失具体微生物名称]、[此处原文缺失具体微生物名称]、[此处原文缺失具体微生物名称]、[此处原文缺失具体微生物名称]和[此处原文缺失具体微生物名称]的活性。除了几种黄酮醇外，在分析的提取物中还鉴定出了“田野百里香”蜂胶的典型成分（如异戊烯基化苯丙素类和咖啡酰奎宁酸）。极性较小的提取物显示出比酒精提取物和水提取物更高的抗支原体活性（最低抑菌浓度值通常为3.9μg/mL），酒精提取物和水提取物的最低抑菌浓度值通常为7.8 - 250μg/mL。结果表明，伊塔帕拉蜂胶是开发治疗药物的一个有前景的来源。
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