Ghahramani Yasamin, Mohammadi Najmeh, Gholami Ahmad, Ghaffaripour Dordaneh
Department of Endodontics, Shiraz Dental School, Shiraz University of Medical Sciences, Shiraz, Iran.
Department of Pediatric Dentistry, Shiraz Dental School, Shiraz University of Medical Sciences, Shiraz, Iran.
Int J Dent. 2020 Dec 21;2020:6669607. doi: 10.1155/2020/6669607. eCollection 2020.
This study aimed to compare the antimicrobial efficacy of calcium hydroxide (CH) and triple antibiotic paste (TAP) against bacteria in infected primary molars.
Thirty-nine 4-6-year-old children with an infected primary molar were randomly divided into three equal groups ( = 13) to receive either CH or TAP and an untreated control group. Following access cavity preparation, the first microbiological samples (S1) were collected by using absorbent paper points. The canals were prepared and rinsed. Then, CH or TAP was applied in the root canals. Seven days later, the second microbiological samples (S2) were collected. DNA extraction was performed to count . bacteria by using real-time PCR for S1 and S2 samples. Data were analyzed through one-way ANOVA and Tukey's test ( = 0.05).
bacteria counts decreased significantly in CH and TAP groups compared with the control group ( ≤ 0.001). However, no statistically significant difference existed between these two groups (=0.698).
Both TAP and CH have significant antimicrobial effects as intracanal medicament between the treatment sessions in infected primary teeth.
本研究旨在比较氢氧化钙（CH）和三联抗生素糊剂（TAP）对感染乳磨牙中细菌的抗菌效果。
39名患有感染乳磨牙的4 - 6岁儿童被随机分为三组（每组 = 13），分别接受CH或TAP治疗，以及一个未治疗的对照组。在开髓后，使用吸水纸尖收集第一批微生物样本（S1）。对根管进行预备和冲洗。然后，将CH或TAP应用于根管内。7天后，收集第二批微生物样本（S2）。通过DNA提取，使用实时PCR对S1和S2样本中的细菌进行计数。数据通过单因素方差分析和Tukey检验进行分析（ = 0.05）。
与对照组相比，CH组和TAP组的细菌计数显著降低（≤ 0.001）。然而，这两组之间没有统计学上的显著差异（= 0.698）。
在感染乳牙的治疗期间，TAP和CH作为根管内药物均具有显著的抗菌作用。
